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- The overexpression of membrane proteins functioning as drug efflux pumps is one of the main mechanisms for multidrug resistance of Candida albicans. 膜转运蛋白高表达导致多药抗药是白念珠菌抗药性产生的最重要机制之一。
- Drug efflux pump 外排泵
- Objective:To explore the role of efflux pump in drug resistance to fluoroquinolones in Stenotrophomonas maltophilia. 目的:探讨主动外排泵在嗜麦芽寡养单胞菌对氟喹诺酮类药物耐药中的作用。
- OBJECTIVE：Specific drug efflux from the endothelial cells of capillary blood vessels of brain mediated by p-glycoprotein(P-gp) is described. 目的：综述脑毛细血管内皮细胞上的P-糖蛋白药物外排功能。
- Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. 多药耐药经常与ATP结合盒蛋白家族（ABC）的药物转运载体的过表达相关。
- The drug-resistance mechaniam of shigella caused by producing inactived enzyme,changing cell walls,target site structure and active efflux pump. 志贺菌的耐药机制主要是产生灭活酶、细胞壁的改变、主动外排以及作用靶位结构的改变。
- ABSTRACT Objective To investigate the role of efflux pump of Acinetobacter baumannii mutant strains against fluoroquinolones. 目的探讨主动外排泵在鲍曼不动杆菌诱导突变株对氟喹诺酮类药物敏感性的影响。
- We have studied the involvement of signal transduction in the regulation of antibiotic biosynthesis, and the genetics and biochemistry of drug efflux in Streptomyces. 我们也研究讯号传导系统参与的抗生素合成的调控，以及链黴菌抗药性的遗传与生化机转。
- P-glycoprotein is an ATP-driven efflux pump which transport a wide variety of structurally diverse compounds from the cell interior into the extracellular space. 糖蛋白是一个能量依赖性转运蛋白,能将许多结构不同的化合物逆向转运出细胞。
- Methods:The effects of cyclosporin A (CsA) on drug sensitivity,intracellular drug accumulation and drug efflux in multidrug resistant human leukemic cell line K562/DOX were studied by MTT colorimetric assay and spectrofluorimetry. 方法：以环孢霉素A（CsA）作为耐药逆转剂，用MTT法体外药物敏感试验，观察CsA对多药耐药白血病细胞株K562/DOX的药物敏感性、细胞内药物的积聚和外排的影响。
- Smyth MJ,Krasovskis E,Sutton VR,et al.The drug efflux Pro tein,P-glyoprotein,additiionally protects drug-Resistant tumor cells from multiple forms of caspase-dependenl apoptosis[J].Proc Natl Acad sci USA,1998,95:7024. 阚兵;罗锋;雷松;等.;用流式细胞术检测肿瘤组织细胞多药耐药基因表达产物[J]
- The acrAB locus encode the efflux pump AcrAB,which confers multidrug tolerance,controlled by the regulon marRAB. Mutation in the gyrase and topoisomerase IV lead to fluoroquinolones resistance, mainly arise in gyrA and parC genes. AcrAB外流泵系统的合成有多重耐药调节子 (marRAB)调控 ,AcrAB与多种抗生素的耐药有关。 拓扑异构酶 (topoisomerase)的突变主要与氟喹诺酮类药物的耐药性有关 ,突变主要发生在gyrA ,parC基因上
- Overexpression or functional abnormality of membrane drug transport proteins of ATP-binding cassette(ABC)family which results in an increased drug efflux,could be one of the main mechanisms. 其中,肿瘤细胞膜上ATP结合盒(ABC)转运蛋白的表达或功能异常是肿瘤细胞产生MDR的重要机制之一。
- It suggested that the level of resistance of isolates would be related to selecting pressure of fluoroquinolones and induced gene mutations of DNase and topoisomerase IV could not activate AcrAB efflux pump system. 提示临床分离的鸡大肠杆菌O 78的耐药水平与喹诺酮类药物的选择性压力有关,它诱导了DNA旋转酶和拓扑异构酶IV的基因突变,可能不能激活A crAB外输泵。
- Objective To study the mechanism of multiple-antibiotic-resistance in clinical isolates of Shigella and to detect the distribution and expression of active efflux pump gene acrAB-tolC. 目的研究志贺菌患者分离株的多重耐药机制。 方法检测志贺菌中有无主动外排系统acrAB-tolC结构基因acrAB-tolC在临床分离菌株中的分布;
- To investigate multiple-antibiotic-resistance mechanism in Escherichia coli, the distribution of active efflux pump gene, acrAB, were determined by PCR, Southern bolt, and its expressions by RT-PCR, in clinical strains of Escherichia coli. 为了研究临床分离多重耐药大肠杆菌的耐药机制，我们采用PCR和Southernblot检测大肠杆菌主动外排系统AcrAB结构基因acrAB在临床分离菌株中的分布并用RT－PCR测定其mRNA表达水平。
- To study the mechanism of multidrug resistance in c1inical isolates of Klebsiella pneumoniae and detect the dis-tribution and expression of active efflux pump gene acrAB, homologous to that in Escherichia coli. 目的:研究临床分离多重耐药肺炎克雷伯菌的耐药机制,检测肺炎克雷伯菌中有无类似大肠埃希菌主动外排系统AcrAB的结构基因acrAB的分布和表达。
- The mechanism of bacterial efflux pumps is one of the important factors resulting in bacterial multidrug resistance. 细菌耐药性,尤其是多重耐药问题日益严重,给临床治疗带来极大的困难。
- Keywords Bacteria;Efflux pump;Multiple drug resistance;Approach; 细菌;外排泵;多药耐药;研究方法;
- This article reviews the clinically relevant bacteria and their pumps, the mechanisms of regulation and the putative natural roles of efflux pumps. 本文主要对近年研究的临床相关细菌及其排出泵、泵的调控机制和可能的生理功能做一综述。
