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- DNA methylating inhibitor makes the transfer of the methyl group to adenine or cytosine impossible,thus the reaction of DNA methylation is inhibited,the genomic methylation level is decreased. DNA甲基化抑制剂使甲基基团不能转移到腺嘌呤或胞嘧啶,导致DNA甲基化反应受阻,从而使基因组甲基化水平降低。
- The state of DNA methylation is reversible,therefore utilization of DNA methylation inhibitors may offer an expectation for prevention and treatment of tumor. 由于DNA甲基化状态是可以改变的,故利用DNA甲基化抑制剂达到防治肿瘤的目的成为可能。
- THE MOLECULAR MECHANISM AND APPLICATION OF DNA METHYLATION INHIBITOR IN THE DEVELOPMENTAL BIOLOGY OF PLANTS DNA甲基化抑制剂作用机理及其在植物发育生物学研究中的应用
- Study on progress of DNA methylation inhibitors 脱氧核糖核酸甲基化抑制剂的研究进展
- DNA methylation inhibitor DNA甲基化抑制剂
- Focus on the bioinformatics analysis of DNA methylation. 甲基化的生物信息学分析。
- DNA methylation is a frequent change in epigenetics of leukemia. 摘要DNA甲基化是白血病表观遗传学改变中较常见的改变。
- DNA methylation plays a key role in transgene silencing. DNA甲基化是引起外源基因沉默的主要原因。
- DNA methylation and its aberrance play an important role in the human development and tumorigenesis. DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用。
- DNA methylation patterns in the CpG island of RASGRF2, RASGRF2 and FBN2 were determined by the method of MSP. 采用 MSP分析 RASSF1A、 RASGRF2 和 FBN2 是否存在启动子异常甲基化。
- Alterations in DNA methylation, an important regulator of gene transcription, lead to cancer. 对调节基因转录起重要作用的DNA甲基化的异常将导致癌症的发生。
- Recent studies on DNA methylation and its regulatory enzymes,seem hot to researches of epigenetics. DNA甲基化及其调节酶是近年来表观遗传学研究的热点。
- The abnormality of DNA methylation includes global hypomethylation and region-specific hypermethylation. DNA甲基化异常包括全基因组的低甲基化和局部基因的高甲基化。
- The advent of microarray technology has provided new opportunities for high-throughput study on DNA methylation. 芯片技术的发展为高通量研究DNA甲基化提供了新的方法。
- DNA methylation is a kind of normal endogenous modified mode,which is fulfilled by DNA methylation transferase. DNA甲基化是真核生物DNA的正常内源性修饰方式,它由DNA甲基化转移酶催化发生。
- In recent years, a variety of methods have been developed to study DNA methylation and other epigenetic modification. 随着研究的不断深入，各种研究方法被开发出来以满足不同类型研究的需要。
- Discussing the relations of DNA methylation and gene transcriptional silencing takes on important significances for the study of many human diseases. 探讨DNA甲基化与基因转录抑制之间的关系,对许多人类疾病的研究具有重要意义。
- Abnormal DNA methylation can influence the expression of certain genes,inducing occurrence and development in autoimmune diseases. DNA甲基化异常可影响某些基因的表达,导致自身免疫性疾病的发生发展。
- DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling. DNA甲基化在基因转录过程中扮有重要角色，并与组蛋白修饰、染色质构型重塑共同参与转录调控。
- So the DNA methylation patterns of mouse tetraploid embryos are aberrant, which may lead to subsequent de-velopmental failure and embryo death. 因此, 小鼠体外培养四倍体胚胎的甲基化模式是不正常的, 这可能是四倍体小鼠难以发育到妊娠足月的原因之一。
