Conclusion: Combined therapy of CM and mecobalamin can improve the clinic presentation, vascular endothelial function and peripheral neuropathy in lower limb in diabetic patients.

• 结论：甲钴胺与马来酸桂哌齐特联合治疗在2型糖尿病合并下肢周围神经病变治疗中可改善血管内皮的功能和下肢周围神经病变，缓解临床症状，疗效显著。