Conclusion): DMD combined with sequential colon dialysis is an effective therapy for patients with CRF and the potential mechanism may be the action of colon dialysis and renal protection of rhubarb.

• 结论:大黄牡公汤联合结肠透析对CRF有明显的疗效,作用机制为肠道透析作用及大黄制剂对肾功能的延缓及保护作用。