Conclusion There was no clear association between ITPA activity and hematotoxicity or hepatotoxicity.AZA induced.The AZA induced gastrointestinal disorders are related to the low ITPA activity.

• 结论硫唑嘌呤所致的血液毒性和肝脏毒性与ITPA活性无明显相关性，硫唑嘌呤所致的胃肠紊乱与ITPA活性低下有关。