Conclusion The appropriate conversion to sirolimus could be a life saving measure in recipients with liver or renal insufficiency after OLT.

• 结论肝移植术后应用钙调磷酸酶抑制剂发生肝肾功能不良或不能达到理想药物浓度时,西罗莫司是有效的抗排斥替代药物。