Conclusion CaN signaling pathway plays an important role in FBs proliferation induced by IP 3, but it is not the single signaling pathway in regulating FBs proliferation, other signaling pathway may be also involved in FBs proliferation induced by IP 3.

• CsA和Ver抑制IP3介导的FBs的CaN活性增高 ,Ver抑制IP3介导的FBs的PKC活性增高。 结论 CaN在IP3剌激的FBs增殖中起重要作用 ,但CaN信号通路不是IP3剌激FBs增殖的唯一信号通路 ,其它信号通路也可能参与了IP3剌激的FBs增殖。