Compound B1,B2 change pharmacokinetics of Venlafaxine, improve competence of penetrate BBB, possess brain-targeting effect, deserve for continued research, B5 excepted.

• 化合物B1，B2改变了文拉法辛的药代动力学性质，提高了其穿透血脑屏障能力，具有脑靶向效应，值得进一步研究； 而化合物B5缺乏该效应。