Compared with 58 healthy controls, 75 patients with medial knee osteoarthritis had decreased blood levels of PIIANP and increased urinary excretion of CTX-II at baseline and at one-year follow-up.

• 将75位中央性骨关节炎的患者与58位健康的人相对照，患者的基线与随访一年之血液PIIANP浓度较低而尿液CTX-II分泌增加。