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- AcSDKP can inhibit proliferation and collagen synthesis in cultured rat cardiac fibroblasts mediated by PDGF. AcSDKP对PDGF介导的心脏成纤维增殖和胶原合成均有明显抑制作用,这可能与其抗心脏纤维化的作用相关。
- AcSDKP further increased MMP-2 and MMP-9 activity and MMP-1 expression of cardiac fibroblasts induced by 10% FBS and PDGF. AcSDKP能够进一步增加由10%25血清和PDGF诱导的心成纤维细胞MMP-2、MMP-9的活性,并促进MMP-1的表达。
- Objective: To investigate the effects of lysophosphatidic acid (LPA) on the proliferation and collagen synthesis of cardiac fibroblasts(CFs) in vitro culture. 目的观察溶血磷脂酸(LPA)对体外培养心脏成纤维细胞(CFs)的增殖与胶原合成的影响。
- Objective To investigate the effects of tetramethylpyrazine (TMP) on the proliferation and collagen synthesis of cardiac fibroblasts (CF) in vitro culture. 目的观察川芎嗪(TMP)对体外培养心脏成纤维细胞(CF)的增殖与胶原合成的影响。
- Myocardium collagen metabolic regulation involves intersitital cells major cardiac fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, and pericytes. 涉及心肌胶原代谢调控的间质细胞主要有成纤维细胞、肌成纤维细胞、平滑肌细胞、内皮细胞、周细胞等。
- Objective To introduce a rapid method of isolateing and culturing cardiac myocyte of neonatal rats and to compare the difference with cardiac fibroblast. 目的 探索一种快速分离和培养新生大鼠心肌细胞的方法，比较心肌细胞和成纤维细胞的形态差异。
- Results: On the culture of 0.4% FBS,PDGF stimulated cardiac fibroblasts proliferation and collagen synthesis with a dose-dependent manner at the concentrations from 1 ng/ml to 20 ng/ml,in which 10 ng/ml PDGF reached its peak. 采用3H-脯氨酸掺入法检测心脏成纤维细胞胶原的合成。 结果:PDGF在1~20 ng/ml浓度范围内对心脏成纤维细胞增殖和胶原合成均有促进作用。
- AIM: To investigate the effects of matrine on the proliferation and collagen synthesis of rat cardiac fibroblasts(CFs) induced by aldosterone(Ald),to research the mechanism of regression of heart fibrosis. 目的：研究苦参碱(Matrine，Mat)对醛固酮(aldosterone，Ald)诱导新生大鼠心肌成纤维细胞(Cardiac Fibroblasts，CFs)增殖及胶原代谢的影响，探讨其抑制心肌纤维化的机制。
- Methods Cardiomyocytes and cardiac fibroblasts were isolated by trypsin digestion method. DNA and protein synthesis were measured by 3 H-deoxythy-midine( 3 H-TdR) and 3 H-Leucine( 3 H-Leu) incorporation. Protein content was measured by Bradford method. 方法采用体外乳鼠心肌细胞和心脏成纤维细胞培养,一定浓度的ET-1、ANP单独或联合作用细胞24h,以3H-胸腺嘧啶脱氧核苷(3H-TdR)、3H-亮氨酸(3H-Leu)掺入法测定细胞DNA、蛋白合成,Brad-ford法测细胞总蛋白含量,RT-PCR法测心肌细胞心钠素ANPmRNA的表达,评价ET-1、ANP对心肌细胞和成纤维细胞的作用。
- Influences of arginine vasopressin and its receptors on iNOS-NO system activity in cardiac fibroblasts 精氨酸加压素及其受体对大鼠心肌成纤维细胞iNOS-NO系统活性的影响
- Calcineurin Mediates the Proliferation of Rat Cardiac Fibroblasts Induced by Arginine Vasopressin 钙调神经磷酸酶调控精氨酸升压素诱导大鼠心脏成纤维细胞增殖的作用
- Calcineurin mediates the collagen synthesis of rat cardiac fibroblasts induced by arginine vasopressin 钙调神经磷酸酶调控血管升压素诱导大鼠心脏成纤维细胞胶原合成的作用
- Calcineurin signaling pathway involved in cultured rat cardiac fibroblasts proliferation 钙调神经磷酸信号通路参与心肌成纤维细胞的增殖
- Effects of Bisoprolol on proliferation and collagen synthesis of cultured cardiac fibroblasts from SHR 比索洛尔对高血压大鼠心肌成纤维细胞增殖及胶原合成的影响
- Effects of Crush Injury Rat Serum on Cell Proliferation in Cultured Cardiac Fibroblasts 挤压伤大鼠血清促心脏成纤维细胞增殖作用
- One example of this kind of cell is the fibroblast. 例如成纤维细胞就属于这种细胞。
- A patient whose heart has stopped beating, as in cardiac arrest. 心脏已停止跳动的病人心脏已停止跳动的病人，如患心脏病
- Most of the nuclei belong to fibroblasts. 大多数核为成纤维细胞核。
- Keywords arginine vasopressin;calcineurin;cyclosporin A;cardiac fibroblasts;proliferation; 精氨酸升压素;钙调神经磷酸酶;环孢素A;心脏成纤维细胞;增殖;
- Keywords N-acetyl-seryl-aspartyl-lysyl-proline;platelet-derived growth factor;cardiac fibroblasts; 酰基-丝氨酰-天门冬酰-赖氨酰-脯氨酸;血小板源性生长因子;心脏成纤维细胞;
