By using of in situ formed orifice technology (ISFOT), delivery orifice of MOP can be formed automatically during tableting and coating process, thus laser drilling machine can be cast aside.

• 原位致孔技术可以使单层渗透泵制剂的释药孔在压片和包衣过程中自然形成，从而避免渗透泵制剂在生产过程中对激光打孔机的依赖，然而，自该技术问世以来，国内外却鲜有关于该技术的研究报道。