Aminoacids that cannot fit into the editing site would be rejected because they are either toosmall to bind tightly at the active site (such as Ala) or have steric hindrance with thesurrounding residues (such as Leu).

• 不适合进编校位点的氨基酸将会被排斥掉,因为它们要么太小以至于不能紧密结合在活性位点(比如Ala) ,要么和蛋白质上口袋中活性位点周围的氨基酸残基有立体化学位阻(比如Leu)。