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- Keywords Type 2 diabetes mellitus Diabetic retinopathy Aldose reductase gene; 2型糖尿病;糖尿病视网膜病变;醛糖还原酶基因;
- Comparison of methods for detecting polymorphism of aldose reductase gene between autoradiograph and silver stain 银染法与放射自显影法检测醛糖还原酶基因多态性的比较
- A study of association between polymorphism of aldose reductase gene and diabetic microangiopathy 醛糖还原酶基因多态性与糖尿病微血管并发症的相关性研究
- Association between polymorphisms of aldose reductase gene and diabetic nephropathy 醛糖还原酶基因多态性与糖尿病肾病的相关性研究
- Polymorphisms and Functions in 5'Regulatory Region of the Aldose Reductase Gene in Chinese Patients with Type 2 Diabetes Mellitus 2型糖尿病患者醛糖还原酶基因5'调控区的多态性与功能
- Polymorphisms and functions of the aldose reductase gene 5'regulatory region in Chinese patients with type 2 diabetes mellitus 中国人2型糖尿病患者醛糖还原酶基因5调控区的多态性与功能
- Aldose reductase Gene 醛糖还原酶
- Objective:To synthesize the aldose reductase inhibitor fidarestat. 目的:合成醛糖还原酶抑制剂非达司他。
- Purpose To study the effects of aldose reductase (AR) gene transfection and AR inhibitors (ARI) on the proliferation of rat mesangial cells (MsC) in vitro. 目的观察醛糖还原酶(AR)基因转染及AR抑制剂(ARI)对体外培养大鼠肾系膜细胞(MsC)增殖的影响。
- Aldose reductase is a key regulatory enzyme in the substrate flux via polyol pathway. 醛糖还原酶是糖代谢多元醇通路的限速酶。
- The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic ad... 醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。
- For screening aldose reductase inhibitors(ARI) from traditional medicinal herbs,the assay method of pig lens AR was established and 40 traditional medicinal herbs were screened. 为从大量中草药及其化学成份中筛选有效低毒的醛糖还原酶抑制剂（ARI），建立了猪晶状体AR的测定方法，其研究了知母等40种中药水提取液对AR的抑制作用。
- Bendazac lysine is a kind of aldose reductase inhibitor.It is an effectual antlcataract drug for improving and keeping person's vision. 苄达赖氨酸为一醛糖还原酶抑制剂,能有效的延缓白内障的进展,起到改善和维持视力的作用,是治疗老年性白内障的有效药物。
- SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. SNK-860是一种新型的海因类醛糖还原酶抑制剂，对醛糖还原酶的抑制作用强而专一，而且不良反应小，是治疗糖尿病性神经病变的安全有效的药物。
- The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%. 对醛搪还原酶抑制剂依帕司他的合成工艺作了改进，使中间体绕丹宁乙酸的收率提高到76．4%25。
- Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. （泡沫细胞形成过程中醛糖还原酶上调可能是糖尿病、高血压和动脉粥样硬化之间的可能联系。）
- It is prospective that new drug development with aldose reductase as a potential target can achieve significant progress. 预计以醛糖还原酶为靶点的新药研究和开发将取得重要进展。
- Using epalrestat as a control, the aldose reductase inhibitory activities of the compounds obtained were evaluated on rat lens aldose reductase in vitro. 以依帕司他为阳性对照药，采用大鼠晶状体醛糖还原酶对目标化合物醛糖还原酶抑制活性进行初步评价。
- Conclusion The structure-activity relationships of methylquinolinoneacetic acids, as a novel type of aldose reductase inhibitor, should be investigated further. 结论 甲基喹啉酮乙酸类化合物作为新型醛糖还原酶抑制剂，其构效关系值得进一步研究。
- Pharmacological experiments of Chinese herbal medicine were focused on antioxidant effect and inhibiting aldose reductase and decreasing apoptosis of lens epithelial cell. 中药制剂的实验药理研究主要集中在抗氧化作用、抑制醛糖还原酶作用和抑制晶状体上皮细胞凋亡方面。
