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- Aldose reductase inhihitor 醛糖还原酶抑制剂
- Objective:To synthesize the aldose reductase inhibitor fidarestat. 目的:合成醛糖还原酶抑制剂非达司他。
- Aldose reductase is a key regulatory enzyme in the substrate flux via polyol pathway. 醛糖还原酶是糖代谢多元醇通路的限速酶。
- The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic ad... 醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。
- For screening aldose reductase inhibitors(ARI) from traditional medicinal herbs,the assay method of pig lens AR was established and 40 traditional medicinal herbs were screened. 为从大量中草药及其化学成份中筛选有效低毒的醛糖还原酶抑制剂（ARI），建立了猪晶状体AR的测定方法，其研究了知母等40种中药水提取液对AR的抑制作用。
- Bendazac lysine is a kind of aldose reductase inhibitor.It is an effectual antlcataract drug for improving and keeping person's vision. 苄达赖氨酸为一醛糖还原酶抑制剂,能有效的延缓白内障的进展,起到改善和维持视力的作用,是治疗老年性白内障的有效药物。
- SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. SNK-860是一种新型的海因类醛糖还原酶抑制剂，对醛糖还原酶的抑制作用强而专一，而且不良反应小，是治疗糖尿病性神经病变的安全有效的药物。
- The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%. 对醛搪还原酶抑制剂依帕司他的合成工艺作了改进，使中间体绕丹宁乙酸的收率提高到76．4%25。
- Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. （泡沫细胞形成过程中醛糖还原酶上调可能是糖尿病、高血压和动脉粥样硬化之间的可能联系。）
- It is prospective that new drug development with aldose reductase as a potential target can achieve significant progress. 预计以醛糖还原酶为靶点的新药研究和开发将取得重要进展。
- Purpose To study the effects of aldose reductase (AR) gene transfection and AR inhibitors (ARI) on the proliferation of rat mesangial cells (MsC) in vitro. 目的观察醛糖还原酶(AR)基因转染及AR抑制剂(ARI)对体外培养大鼠肾系膜细胞(MsC)增殖的影响。
- Using epalrestat as a control, the aldose reductase inhibitory activities of the compounds obtained were evaluated on rat lens aldose reductase in vitro. 以依帕司他为阳性对照药，采用大鼠晶状体醛糖还原酶对目标化合物醛糖还原酶抑制活性进行初步评价。
- Conclusion The structure-activity relationships of methylquinolinoneacetic acids, as a novel type of aldose reductase inhibitor, should be investigated further. 结论 甲基喹啉酮乙酸类化合物作为新型醛糖还原酶抑制剂，其构效关系值得进一步研究。
- Pharmacological experiments of Chinese herbal medicine were focused on antioxidant effect and inhibiting aldose reductase and decreasing apoptosis of lens epithelial cell. 中药制剂的实验药理研究主要集中在抗氧化作用、抑制醛糖还原酶作用和抑制晶状体上皮细胞凋亡方面。
- The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic adjuncts in treating evolving myocardial infarction. 醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。
- OBJECTIVE: To observe the effect of aldose reductase inhibitor(ARI) on the activity of corneal aldose reductase (AR) and Na+-K+ATPase , and on corneal lesions in early diabetic rats and to investigate the protective mechanism. 目的:观察醛糖还原酶抑制剂(ARI)对糖尿病早期大鼠角膜组织中醛糖还原酶活性(AR)、钠-钾-ATP酶活性(Na+-K+ATPase)和角膜病变的影响,并探讨其防治效应及其机制。
- Support vector regression (SVR), a powerful machine learning technology based on statistical learning theory (SLT) was applied to QSAR on the aldose reductase inhibitory activity of 48 flavones. 用支持向量机回归(SVR)方法研究了48个黄酮类化合物醛糖还原酶抑制活性的定量构效关系。
- Part IIThe second part of this thesis is the synthesis of the aldose reductase inhibitor SNK-860. SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. 本论文的第二部分是醛糖还原酶抑制剂SNK-860的合成研究。 SNK-860是一种新型的海因类醛糖还原酶抑制剂，对醛糖还原酶的抑制作用强而专一，而且不良反应小，是治疗糖尿病性神经病变的安全有效的药物。
- According to investigations on animals, it is shown that TangLuoTong can anti-coagulate, thrombolysis, distend vessels, reduce blood viscosity and has actions like aldose reductase inhibitors. 经动物研究发现糖络通能抗凝、溶栓、扩张血管、降低血液粘度，并有一定的醛糖还原酶抑制剂样作用；
- Pyridazinone derivatives have considerable kinds of biological activities such as those cardiotonic,platelet aggregation inhibitory,anti-inflammatory,aldose reductase inhibitory,antifungal and so on. 哒嗪酮类化合物具有多种重要的生物活性,根据作用机制的不同,可分为钙增敏剂、磷酸二酯酶抑制剂、环氧合酶抑制剂等,并可用于相关疾病的治疗。
