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- Determination of activity of new antifolate thymidylate synthase inhibitor ZD1694 against cancer cell lines in vitro 新一代抗叶酸胸苷酸合成酶抑制剂ZD1694的体外抗肿瘤活性(英文)
- Keywords DNA methyltransferase inhibitor;thymidylate synthase inhibitor;dru g combination;antitumor; DNA甲基化转移酶抑制剂;胸苷酸合成酶抑制剂;联合用药;抗肿瘤;
- Keywords medicinal chemistry;thymidylate synthase inhibitor;raltitrexed;synthesis; 药物化学;胸苷酸合成酶抑制剂;雷替曲塞;合成;
- thymidylate synthase inhibitor 胸苷酸合成酶抑制剂
- Objective To detect the polymorphism in t he thymidylate synthase promoter enhancer region (TSER) in primary gastrointesti nal cancer. 目的检测原发性胃癌、结直肠癌胸苷酸合成酶(TS)启动基因增强子区段(TSER)的多态性。
- Using chromosome DNA of Lactobacillus casei 34103 as template, thy A (Thymidylate synthase) gene was amplified by PCR with pfu DNA polymerase. 以干酷乳杆菌L.;casei34103染色体DNA为模板，利用PCR技术扩增胸苷酸合成酶(Thymidy-1atesynthase，fhyA)基因，回收纯化。
- Objective To observe the expression of thymidylate synthase(TS) in gastric \{carcinoma\} and its relationships with clinicopathological characteristics and prognosis. 目的观察胃癌中胸苷酸合酶(TS)的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后的关系,探讨TS的临床病理学意义。
- Abstract:Objective:To investigate the effect of inducible nitric oxide synthase inhibitor aminoguanidine on transplanted pancreas in rats. 目的:探讨诱导型一氧化氮合酶抑制剂氨基胍对大鼠移植胰腺的保护作用。
- Abstract：Objective To discuss effect of collagen expression in articular cartilage repaire tissue by inducible nitric oxide synthase inhibitor SMT. 既往研究虽然采用了多种方法促进软骨修复，许多报告均能在早期获得缺损区透明软骨的生成。
- Objective To observe the expression of thymidylate synthase(TS)and thymidine phosphorylase(TP)in colorectal carcinoma and its relations with clinicopathological characteristics and prognosis. 目的观察结直肠癌中胸苷酸合酶(TS)、胸苷磷酸化酶(TP)的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后的关系,探讨TS、TP的临床病理学意义。
- Objective: The effects of nitr ic oxide(NO)and NO synthase inhibitor on endotoxin(ETX)-in- duced CGRP release from rat spinal cord in vitro were studied. 目的：探讨一氧化氮（NO）及NO合成酶（NOS）抑制剂对内毒素引起的大鼠脊髓降钙素基因相关肽（CGRP）释放的影响。
- Aminoguanidine (AMG), a specific inducible NO synthase inhibitor (100 M, 1 mM), inhibited the effect of LPS, while 10M AMG did not inhibit the effect of LPS. iNOS特异性抑制剂AMG孵育LPs处理过的主动脉环1小时，对主动脉低反应的抑制作用呈浓度依赖性，roo林M和lmM的AMG能完全取消LPS引起的主动脉环的低反应性，10“M的AMG则没有这个效果。
- Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME, 0.5 mmol/L), a nitric oxide (NO) synthase inhibitor, did not affect the effects of GST on AV node cells. （4）NO合酶阻断剂L-NAME(0.;5 mmol/L)对GST的效应无影响。
- NO donor L Arg and ET receptor antagonist TAK 044 could alleviate the hepatic I/R injury in some degree, whereas NO synthase inhibitor L NAME aggravated the damage. NO供体L 精氨酸 (L Arg)与ET受体拮抗剂TAK 0 44在一定程度上可减轻肝I/R损伤 ,而NO合酶抑制剂L NAME进一步加重了损伤。
- Objective To explore the role of endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine(ADMA) in different factors-induced gastric mucosal injury. 目的:研究一氧化氮合酶抑制物非对称性二甲基精氨酸(ADMA)在不同因素诱发的胃黏膜损伤中的作用,并初步探讨其机制。
- In this experiments, buthionine sulfoximine (BSO), a GSH synthase inhibitor used to adjust intracellular GSH content, was observed its radiosensitization effect in vivo and in vitro. 评价GSH合成抑制剂-丁胱亚磺酰亚胺(BSO)的辐射增敏效果,探讨以外周血单核细胞中GSH含量监测肿瘤患者对射线敏感性的可行性。
- NO synthase inhibitor:NG-Nitro-L- arginine(L-NNA),NG-nitro-L-arginine methyl ester (L-NAME),NG-monomethyl-I-arginine acetate(L-NMMA),7-Nitroindazole had no effects on basel and the ETX-induced CGRP release from spinal cord in uitro. 各种NOS抑制剂L－NNA，L－NAME，L－NMMA和7－NI对离体大鼠脊髓CGRP的基础释放以及内毒素引起的CGRP释放均无明显影响。
- Keywords Colonic neoplasms;Thymidylate synthase;Single nucleotide;polymorphism; 结肠肿瘤;胸苷酸合酶;单核苷酸;多态性;
- Keywords Stomach neoplasms;Thymidylate synthase;Immunohistochemistry; 胃肿瘤;胸苷酸合成酶;免疫组织化学;
- Keywords nolatrexed;thymidylate synthase;protein expression;drug resistance; 洛拉曲克;胸苷酸合成酶;蛋白表达;耐药性;
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- 深远海浮式风电平台 - deep-sea floating wind power platform
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- 京雄高速公路 - Beijing-Xiongan expressway
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- 农业及相关产业增加值 - the added value of agriculture and related industries
