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- The team injected the iruses into a part of the brain called the subthalamic nucleus, which becomes oeractie in patients with Parkinson's disease. 研究人员将病毒注射到一个叫做底丘脑核的脑区,在帕金森患者中这个脑区变得异常兴奋。
- It entails placing electrodes on the subthalamic nucleus (or nearby areas) and stimulating it with a pace-makerlike device to achieve benefits similar to lesioning. 深部脑刺激术的做法是将电极埋于视丘下核(或附近区域),然后以类似节律器的装置进行刺激,获致与破坏相同的效果。
- Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. 在这个位点的治疗刺激一般采用低频刺激而不是像亚丘脑核这样使用高频刺激。
- Limousin P, Krack P, Pollak P, et al.Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.N Engl J Med, 1998,339(16): 1105. 李殿友;孙伯民;孙成彦;等.;双侧丘脑底核电刺激对帕金森病患者脑局部糖代谢的影响
- The gene was packaged in a virus and patients were given injections of billions of copies of the genetically altered viruses into part of the brain called the subthalamic nucleus. 这种基因被装在一个病毒患者注射的数十亿份的转基因病毒进入的部分大脑称为丘脑底核。
- The subthalamic nucleus (STN), which is located in the indirect pathway of the basal ganglia circuitry, has been regarded as an important modulator of basal ganglia output. 底丘脑核(Subthalamic nucleus, STN)位于基底神经节环路的间接通路上,对基底神经节的传出活动具有重要的调节作用。
- "DBS of the subthalamic nucleus selectively enhanced affective processing and subjective well-being and seemed to be antidepressive.Levodopa and DBS had similar effects on emotion," the authors write. 下丘脑核DBS选择性提高情感活动和主观感觉,似乎是抗忧郁的作用,左旋多巴和DBS对情感有相似的作用。
- A microelectrode is implanted into the subthalamic nucleus to provide stimulating current generated by the lab-built stimulator that could adjust the release of the neurotransmitter. 现今的主要治疗方式则分为药物与外科手术的治疗,初期患者是以服用药物为主,当所需药物的量越大时,就必须施以外科手术治疗。
- Bilateral deep brain stimulation at the subthalamic nucleus for treating idiopathic Parkinson's disease 双侧丘脑底核电刺激治疗原发性帕金森病
- Establishment and adjustment of parameters for deep brain stimulation of the subthalamic nucleus 丘脑底核脑深部刺激术的参数设置及调整
- Keywords Parkinson s disease(PD) Deep brain stimulation(DBS) The subthalamic nucleus(STN); 帕金森病;脑深部电刺激;丘脑底核;
- The changes of neurotransmitters in the corpus striatum of hemiparkinsonian rhesus monkeys after deep brain stimulation of the subthalamic nucleus 丘脑底核电刺激对猴偏侧帕金森病纹状体神经递质的影响
- “Stimulation is delivered to one of two regions in the brain known as the subthalamic nucleus or the globus pallidus interna to influence nerve cell activity in these regions. 刺激被传到丘脑底核或内苍白球的其中一个区域来影响这些区域的神经细胞的活动。
- [8]Sun BM, Liu KY, Lang LQ, et al.Bilateral deep brain stimulation of the subthalamic nucleus in advanced Parkinson's disease[J].Chin J of Nurosurgery,2002,18(1):8-11. 孙伯民;刘康永;郎黎琴;等.;双侧丘脑底核脑深部电刺激治疗帕金森病[J]
- the subthalamic nucleus 丘脑底核
- Effects of the high frequency stimulation to the subthalamic nucleus on the rotation behaviour and the excitatory amino acids and dopamine content in striatum in rats with Parkinson's Disease 高频电刺激丘脑底核对帕金森病大鼠旋转行为及纹状体多巴胺和兴奋性氨基酸的影响
- Keywords chronic brain deep stimulation(DBS);parkinson s disease(PD);essential tremor(ET);the subthalamic nucleus(STN);the ventrointermidius nucleus of the thalamus(Vim); 脑慢性深部电刺激;帕金森病;特发性震颤;丘脑底核;丘脑腹中间核;
- Mechanisms of the subthalamic nuclei high frequency stimulation in Parkinson's disease 丘脑底核高频电刺激治疗帕金森病的机制
- The influence of the subthalamic nuclei high frequency stimulation on striatal dopaminergic metabolism in the rat 丘脑底核高频电刺激对大鼠纹状体多巴胺代谢影响的研究