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- telomeric hyperreactivity 端粒高反应性
- ObjectiveTo investigate the effect of peroxynitrite anion(ONOO -) on airway hyperreactivity. 目的探讨过氧亚硝基阴离子(ONOO-)在气道上皮细胞损伤致气道高反应性中的作用。
- ResultsThe exposure of tracheal strips to peroxynitrite led to epithelial damage and hyperreactivity to histamine. 结果豚鼠气管条与ONOO-孵育后,气管条的反应性增高,同时电镜观察有气道上皮细胞损伤脱落。
- No deletions of SMN in the telomeric were found in the other numbers of families and controls. 家系其他成员及对照组均无SMN端粒基因缺失。
- Objective To evaluate the telomeric restriction fragment in the progress of gastric tumorigenesis. 目的探讨不同胃粘膜病变端粒状态的变化规律。
- Asthma is a disease characterized by airway hyperreactivity to nonspecific stimuli.Stimuli such as the endotracheal tube may cause bronchoconstriction. 哮喘是气道对非特异性刺激具有高反应性为特点的一种疾患,如气管插管等刺激可导致支气管收缩。
- Telomerase activity of GBC SD cells was examined by telomeric repeat amplification protocol (TRAP). TRAP法检测端粒酶活性,流式细胞仪检测细胞周期及凋亡情况,电镜观察细胞微观形态变化。
- The results of the higher serum vitamin D concentrations are associated with longer leukocyte telomer length in women. 妇女血清高维生素D浓度的这一结论与白细胞调聚物的长度较长有关。
- Objective To investigate the relationship between the telomer ase activity and apoptosis in gastric cancer. 目的为了探讨胃癌组织中端粒酶与细胞凋亡的关系。
- Kaufman J,Casanova JE,Piendl P,et al.Bronchial hyperreactivity and cough due to angiotension converting enzyme inhibitors[J].Chest,1989(95):544. 叶阮健;何权瀛;改军;等.;高血压患者服用血管紧张素转换酶抑制剂后咳嗽机制的前瞻性研究[J]
- Telomerase is capable of synthesizing telomeric DNA onto the ends of chromosomes, compensating the telomeric sequences lost and making cell immortal. 但端粒酶的存在却可以维持细胞端粒的长度,使细胞可以逃避凋亡而具有“不死性”。
- Telomeric proteins is composed of double DNA binding protein, single DNA binding protein and telomeric associated proteins. 端粒结合蛋白直接保护端粒DNA,端粒相关蛋白通过与端粒结合蛋白的相互作用间接影响端粒的功能。
- Methods:The telomeric repeat amplification protocol(TRAP)combined with densitometry and clinical examination were performed in leukemia patients. 方法:端粒重复扩增法结合吸光度测定及临床病例分析。
- Telomerase activity was determined by the telomeric repeat amplification protocol enzyme-linked immunoassay (TRAP -ELISA). 应用TRAP-ELISA法测定肾上腺肿瘤中的端粒酶活性。
- Our current results point to potent protective effects of DI on peripheral parts of chronically inflamed murine lungs and that the presence of DI may blunt airway hyperreactivity. 本研究旨在探讨健康鼠、急性和慢性气道炎症小鼠模型中,机械通气过程中DI对于肺部机械力学的影响。
- For replicative senescence in one-celled organisms, telomeric ageing is clearly a \'feature\' of the genetic software, not a bug. 对单细胞生物体的复制性衰老而言,端粒的老化显然是基因程序的一个\\'特点\\',而不是基因程序上的一个瑕疵。
- Conclusion: The result showed that terminal deletion of Xq and telomeric deletion of X chromosome were important factors of premature ovarian failure. 结论:本文的研究结果提示X染色体长臂末端可能是卵巢早衰的特异性基因区段并与X染色体末端端粒的缺失有关。
- The G-rich single-stranded telomeric DNA can adopt in vitro a variety of different non-B-DNA conformations such as an intramolecular quadruplex structure (G4-DNA). 端粒DNA序列在K~+、Na~+等离子的存在下能够形成稳定的G4-DNA结构,这种结构阻碍了端粒酶对端粒DNA引物的识别,从而抑制了端粒酶的表达。
- Methods The telomeric repeat amplification protocol (TRAP)combined with semiquantitative analysis and clinical obsevation of arsenic trioxide treatment in leukemic patients. 方法端粒重复扩增法结合光密度测定和临床治疗观察。
- The telomerase activity in mouse oocyte and preimplantation embryo was examined using the polymerase chain reaction-based on telomeric repeat amplification protocol (TRAP). 摘要为了解小鼠早期发育过程中端粒酶的活性变化,本研究利用端粒重复序列扩增法(TRAP)进行了小鼠卵母细胞和附植前胚胎端粒酶活性的测定。