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- It has been proved that HSV-TK/GCV was the most representative suicide gene therapy system. 研究背景与目的自杀基因治疗是一种重要的肿瘤基因治疗策略,也是肿瘤研究的热点课题之一。
- Objective:To compare the tumor-inhibition effect of ACV and GCV invitro in suicide gene therapy experiment for malignant tumor. 目的 :用含有HSV -TK基因的重组腺病毒/丙氧鸟苷系统(AdTK/GCV)及该重组病毒/无环鸟苷系统(AdTK/ACV) ,在体外分别对4种肿瘤细胞进行抑瘤实验 ,比较GCV、ACV对肿瘤细胞的抑制效果。
- This review focuses on recent advances in gene therapy for colorectal cancer, including suicide gene, immunotherapy, antiangiogenesis gene and combined therapy. 本文综述了自杀基因、免疫基因、抗肿瘤血管基因及联合治疗大肠癌等最新研究进展。
- Con-elusion:The suicide gene therapy system using an ovarian-specific promoter by polyethylenimine mediated transfection has a targeting killing activity on human ovarian cancer. 结论:多聚乙烯基亚胺介导的卵巢特异性启动子调控下的自杀基因对卵巢癌有靶向杀伤作用。
- Objective To investigate the killing effect of herpes simplex virus thymidine kinase/gancyclovir (HSV tk/GCV) suicide gene therapy system on retinoblastoma (Rb) cells and the mechanism of bystander effect. 目的 研究单纯疱疹病毒胸腺嘧啶核苷激酶 /更昔洛韦 (herpessimplexvirusthymidinekinase /gancyclovir,HSV tk/GCV)自杀基因系统对视网膜母细胞瘤 (retinoblastoma ,Rb)细胞的体外杀伤作用以及旁观者效应发生的机制。
- Study on Suicide Gene Therapy of Malignant Glioma 自杀基因治疗恶性胶质瘤的研究
- Keywords Retrovirus;Suicide gene;Bile duct neoplasms;Gene therapy; 关键词逆转录病毒;自杀基因;胆管肿瘤;基因治疗;
- Keywords Retrovirus;Suicide gene;Cell;Lymphoma;Gene therapy; 反转录病毒;自杀基因;细胞;淋巴瘤;基因治疗;
- HIF-dependent suicidal gene therapy system Ad-5HRE/hCMVmp-BCD/5-FC can be used as a powerful therapeutic method for renal cell carcinoma. HIF依赖性表达的Ad-5HRE/hCM-Vmp-BCD/5-FC自杀基因系统可显著抑制肾细胞癌生长,具有良好的临床应用前景。
- Adeno-associated virus vector and it's mediation in suicide gene therapy 腺相关病毒载体及其介导的自杀基因疗法
- Keywords colorectal tumor;KDR promoter;suicide gene therapy;lentivirus; 大肠肿瘤;KDR启动子;自杀基因治疗;慢病毒;
- Keywords Somatostatin Receptor;Reporter Gene;Gene Therapy;Suicide Gene;Imaging; 生长抑素受体;报告基因;基因治疗;自杀基因;显像;
- Hypoxia-targeted suicidal gene therapy system Ad-5HRE/hCMVmp-BCD/5-FC could enhance antitumor effects of radiotherapy on pancreatic cancer and can be used as a powerful adjunct to conventional radiotherapy. 乏氧靶向性的Ad-5HRE/hCMVmp-BCD/5-FC自杀基因系统可显著增强胰腺癌细胞的放疗效果,具有良好的临床应用前景。
- Suicide Gene Therapy for Rat Bladder Carcinoma Entailing Instillation of Bladder via Urethra 经尿道灌注自杀基因治疗大鼠膀胱癌的实验研究
- The comparative study on GCV and ACV tumor- inhibition effect in vitro in malignant tumor suicide gene therapy 恶性肿瘤自杀基因治疗中GCV和ACV体外抑瘤作用的比较研究
- Relationship between the expression of connexin 43 and bystander effect of suicide gene therapy in ovarian cancer 卵巢癌自杀基因治疗的旁观者效应及其与间隙连接蛋白43表达的关系
- The effects of suicide gene therapy system on adenoid cystic carcinoma of salivary gland in athymic mice 涎腺腺样囊性癌自杀基因治疗的实验研究
- X-ray combined with cytosine deaminase suicide gene therapy enhances killing of colorectal carcinoma cells in vitro X线联合胞嘧啶脱氨酶基因对结肠直肠肿瘤细胞的杀伤作用
- Adenovirus-mediated double suicide gene therapy for experimental bladder carcinoma 腺病毒介导融合双自杀基因治疗膀胱癌
- Effect and clinical significance of double suicide gene therapy on colorectal carcinoma cells 大肠癌细胞的双自杀基因治疗