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- Specific Expression of Suicide Gene in Liver Cancer?Cells Mediated by Adenovirus ?? 腺病毒载体介导的肝癌细胞专一性自杀基因表达
- It has been proved that HSV-TK/GCV was the most representative suicide gene therapy system. 研究背景与目的自杀基因治疗是一种重要的肿瘤基因治疗策略,也是肿瘤研究的热点课题之一。
- Including antisense oligonucleotides, ribozymes, at the wrong virus interferents, such as cell suicide gene. 包括反义核苷酸、核酶、缺陷病毒的干扰剂、细胞自杀基因等。
- Objective:To compare the tumor-inhibition effect of ACV and GCV invitro in suicide gene therapy experiment for malignant tumor. 目的 :用含有HSV -TK基因的重组腺病毒/丙氧鸟苷系统(AdTK/GCV)及该重组病毒/无环鸟苷系统(AdTK/ACV) ,在体外分别对4种肿瘤细胞进行抑瘤实验 ,比较GCV、ACV对肿瘤细胞的抑制效果。
- Aims: To investigate the killing effects of PNP/fludarabine suicide gene system on human hepatocellular carcinoma cell line BEL7402 in vitro. 目的:研究PNP/fludarabine自杀基因系统对人肝癌细胞系BEL7402的体外杀伤效应。
- The MIT researchers have previously used an unmodified version of the polymer to selectively deliver a suicide gene to prostate tumors in mice. MIT研究人员曾用一种未修饰的聚合物将一个自杀基因选择性地运送到小鼠的前列腺肿瘤中。
- The former approach is technically simpler in mice but less promising in some ways: for example, cells that undergo silencing of the suicide gene are permanently un-killable. 在小鼠中,前一条途经在技术上较为简单,但是在某些情形下前途有限:例如,自杀基因沉默的细胞永远不能被杀死。
- This review focuses on recent advances in gene therapy for colorectal cancer, including suicide gene, immunotherapy, antiangiogenesis gene and combined therapy. 本文综述了自杀基因、免疫基因、抗肿瘤血管基因及联合治疗大肠癌等最新研究进展。
- Con-elusion:The suicide gene therapy system using an ovarian-specific promoter by polyethylenimine mediated transfection has a targeting killing activity on human ovarian cancer. 结论:多聚乙烯基亚胺介导的卵巢特异性启动子调控下的自杀基因对卵巢癌有靶向杀伤作用。
- Objective To investigate the killing effect of herpes simplex virus thymidine kinase/gancyclovir (HSV tk/GCV) suicide gene therapy system on retinoblastoma (Rb) cells and the mechanism of bystander effect. 目的 研究单纯疱疹病毒胸腺嘧啶核苷激酶 /更昔洛韦 (herpessimplexvirusthymidinekinase /gancyclovir,HSV tk/GCV)自杀基因系统对视网膜母细胞瘤 (retinoblastoma ,Rb)细胞的体外杀伤作用以及旁观者效应发生的机制。
- Objective To study the killing effect of suicide gene TK to murine gastric cancer and observe the role of immune response in enhancing TK killing capacity following TK gene combined with mGM-CSF gene. 目的 观察自杀基因TK对小鼠胃癌的杀伤作用 ,并联合mGM CSF基因 ,观察免疫反应在增强TK杀伤性中的作用。
- Conclusion:Fusion suicide gene Fcy::Fur combined with 5-fluorocytosine could significantly kill HO-8910, and the growth inhibition rate(GIR) increased remarkablely compared with the control. 融合型自杀基因Fcy::Fur联合5一Fc可对卵巢癌细胞株HO一8910产生明显的杀伤作用;
- Objective: To investigate the effect of latent membrane protein 1 of Epstein-Barr virus (EBV-LMP1 ) on HIV-LTR through the NF-B and role of the expression of suicide gene in cancer therapy. 目的:研究EB病毒潜伏膜蛋白1(EBV-LMP1)通过活化NF-kB反式激活HIV-LTR进而启动自杀基困HSV-tk在EBV相关肿瘤治疗中的作用,为进一步开展肿瘤治疗提供科学的实验依据。
- As a result,the cells will be killed.Radionuclide labeled probe can display the biologic characteristics of suicide gene in vivo.This article reviews the development of HSV-tk gene imaging. 利用放射性核素标记的探针可以显示自杀基因在体内的生物学特性,起到基因治疗的监测作用,其中研究最多的是单纯疱疹病毒胸苷激酶自杀基因显像。
- Abstract: Objective: The aim of this study was to investigate vitro/vivo killing effect of suicide gene CD on the human gastric cancer cell line 7901 by gene transfection method. 摘 要: 目的:通过转基因方法观察自杀基因CD对人胃癌细胞株7901的体内外杀伤作用,并观察组织病理变化。
- Progress in treatment of tumor suicide gene 肿瘤自杀基因治疗研究进展
- Study on Suicide Gene Therapy of Malignant Glioma 自杀基因治疗恶性胶质瘤的研究
- Keywords Suicide gene;HSP PC;Antitumor effect; 自杀基因;热休克蛋白-多肽复合物;抗肿瘤效应;
- I read about the writer's suicide in an evening newspaper. 我是从一份晚报上读到关于那位作家自杀的消息的。
- Her suicide was motivated by desperation. 她自杀的诱因是自暴自弃。