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- Up to date, strontium ranelate displays safety and effectiveness in the clinical study. 在迄今为止的临床试验中,雷奈酸锶显示了很好的安全性和有效性。
- The mechanism of pharmacology and recent advance in clinical trials of strontium ranelate are reviewed in this paper. 本文就雷奈酸锶目前的药理及临床研究进展作一综述。
- In ovariectomized rats, strontium ranelate decreases bone resorption but maintains high bone formation, resulting in increased bone mass and strength. 在卵巢切除大鼠,雷奈酸锶在保持高水平骨形成的同时抑制骨吸收,增加骨量和骨的强度。
- METHODS Strontium ranelate was synthesized from citric acid via decarboxylation,esterification,cyclization,alkylation,hydrolysis and salification. 方法以枸橼酸为起始原料,经过脱羧、酯化、环合、烷基化、水解成盐等多步反应生成终产物雷尼酸锶。
- In vivo, strontium ranelate can increase bone formation, reduce bone resorption and improve bone microstructure in normal mice or rats. 在体内,雷奈酸锶可使正常的大鼠和小鼠骨形成增强和骨吸收降低,并可改善骨的微细结构。
- A lot of animal experiments and clinical trials have proven that strontium ranelate not only can prevent bone absorption but also promote hone formation. 大量的动物实验和临床试验研究表明雷奈酸锶是一种既具有抗骨吸收,又能促进骨形成的药物。
- In histomorphometric analysis, the osteoblast surface and mineral apposition rate increased whereas bone resorption parameters decreased in strontium ranelate treated patients. 组织测量学研究显示,雷奈酸锶可以使成骨细胞的表面和骨的矿物质沉积率增加,而骨吸收的参数下降。
- Strontium ranelate is a new available medicine in the treatment of osteoporosis possessing effective prevention and treatment for osteoporosis especially in the management of hone fracture induced by postmenopausal asteoporosis. 摘要雷奈酸锶是一种新近上市的治疗骨质疏松药物,能够有效预防和治疗骨质疏松症及绝经后妇女骨质疏松引起的骨折。
- Although the mechanism of action is still under rigorous research, strontium ranelate stimulates preosteoblast proliferation, differentiation and bone matrix synthesis in rat or mouse culture system. 尽管其机制尚不清楚,但在组织和细胞培养中,雷奈酸锶可以促进前成骨细胞的增生和分化,促进骨基质的合成。
- Current status of strontium ranelate 雷奈酸锶研究现状
- Strontium Ranelate: A New Treatment for Postmenopausal Osteoporosis 锶盐:一种治疗绝经后骨质疏松症的新思路
- New emerging therapy for osteoporosis: Strontium Ranelate Chui Kin Yuen 骨质疏松症的新治疗方法
- Strontium ranelate for the treatment of osteoporosis Is useful, but changes in bone mineral density need careful interpretation 雷尼酸锶治疗骨质疏松治疗有效,但应慎重解释骨矿物质密度变化
- strontium ranelate 雷奈酸锶
- Barite usually contain strontium and calcium. 重晶石常含锶和钙。
- Strontium, introduced as its ranelate salt, has both anti-resorbing and bone forming effects and is remarkably effective in preventing both vertebral and non-vertebral fractures. 、锶盐能保持骨形成的同时减少骨吸收,有效降低椎体和非椎体骨折率。
- Strontium can avoid cancellous bone and cardiovascular disease. 锶:可防治骨质疏松和心血管病。
- STUDY ON SEPARATION AND PURIFICATION OF HIGH-PURITY STRONTIUM OXIDE. 高纯氧化锶的分离提纯研究。
- Weekly testing for ammonia, nitrite, nitrate, turbidity, iodide, and strontium. 每周测试氨氮,亚硝酸盐,硝酸盐氮,浊度,碘,锶。
- Strontium cobaltite, however, is hardly used in the environmental protection. 但目前对钴酸锶在环境保护中的应用研究甚少。