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- Studies have shown that nearly 100% of large molecular drugs and 98% of small molecular drugs can not penetrate across the blood-brain barrier (BBB). 研究表明100%25的大分子药物和98%25的小分子药物不能透过血脑屏障(Blood-Brain Barrier, BBB)。
- Keywords LC/APCI/MS;small molecular drugs;metabolism;excretion; MS法;小分子药物;代谢;排泄;
- Howeer, the use of nanoparticles for small molecular weight, water-soluble drugs has been limited by poor drug encapsulation efficiency and rapid release of the encapsulated drug. 然而，使用纳米粒包裹小分子量的水溶性药物，会受药物包囊效率低及包囊药物快速释放差的限制。
- The TFF peptides are a family of small molecular regulatory proteins, including TFF1 (PS2) ,TFF2 (SP) and TFF3(ITF). 三叶肽是一族富含半胱氨酸的小分子多肽,主要由乳癌相关肽、解痉多肽和肠三因子组成。
- Antimicrobial peptides have small molecular weight, high heat stability and a wide antimicrobial spectrum. 摘要抗菌肽具有分子量小、热稳定性和广谱抗菌等特点。
- They have small molecular mass, good thermostability and antigenicity.They have broad spectrum-antibacterial activity. 它具有较小的分子质量，良好的耐热性和较小的抗原性，且具有广泛的抗菌活性。
- AZT can inhibit the telomerase activity and induce apoptosis of SMMC-7721 cells, which is related to specific small molecular proteins. AZT可抑制SMMC-7721细胞端粒酶活性,诱导凋亡与相关特异小分子蛋白有关。
- AIM: To construct 3D QSAR models of drugs passing through the blood brain barrier (BBB), that provide a theoretical basis for molecular drug design. 目的：建立药物透过血脑屏障的三维构效模型，为药物分子设计提供理论依据。
- In this paper we studied the interactions of small molecular and water using the B3LYP, MP2 and HF methods at different basis sets levels. 在本论文中我们运用了高水平从头算方法(主要采用B3LYP、MP2和HF方法,并考虑不同的基组水平的影响),详细系统地研究了小分子与水分子氢键络合物体系。
- Isolated gravitationally bound small molecular clouds with masses less than a few hundred times the mass of the sun are called Bok globule. 孤立的、引力束缚的，质量在数百个太阳质量以下的小分子云称为包克球。
- Running water purified by our machine will be axenic, softer and mineralize, called alkalescent small molecular group water. 该产品可以将目前的自来水处理成为抗菌、净化、软化、矿化并具有高能量的弱碱性小分子团活化水。
- Small molecular reaction include diazonium salts, initiator decompose free radicals, carbene free radicals, and nitrene free radicals. 用于改性碳纳米管的小分子自由基包括芳香偶氮盐、过氧化物分解产生的自由基、卡宾与乃春自由基等；
- The densest parts of small molecular clouds are equivalent to the molecular cores found in GMCs and are often included in the same studies. 在这种小分子云中密度最高的区域与在巨分子云的分子云核等价，因此常出现在同样研究之中。
- Aquaglyceroporin is a kind of water channels(aquaporins) which can transport both water and other small molecular substances,such as glycerol. 水甘油通道蛋白是一类既可以运输水分子,又可以运输甘油等小分子物质的水通道蛋白。
- An acrylic alkyd was produced via monoglyceride, in which acrylic prepolymer containing carboxyl with small molecular weight was applied as a modifier. 摘要采用单甘油酯法成功地制备出表干快、硬度高、耐候性好的丙烯酸改性醇酸树脂自干型涂料，可满足户外大型钢结构的涂装要求。
- Defensins were a family of small molecular peptides that are capable of killing microbe and they present in life-form bound abroad. 防御素是生物界广泛存在的一类具微生物抗性的低分子肽,其抗菌谱最广,具有很高的应用潜力。
- The small molecular Europium(III) complexes were dissolved in certain organic solvent and formed clear films upon the UV curing or thermal curing. 先将小分子的甲基丙烯酸铕溶于一定的有机溶剂经磁力搅拌或者超声辐照后与预聚物共混UV固化或者热固化成膜，对制备条件对杂化涂层荧光性能和磁学性能影响进行了表征。
- The results show that small molecular phases fill or adsorpt in the pores and high molecular net structure in the "continuous phases" form of interlaced and speckled of raw coals. 结果表明：原煤中小分子相是以“连续相”均匀混杂、互相交织的形式填充或吸附在煤的孔隙和大分子网络结构中。
- The research progress of 1,8-naphthalimide as organic small molecular Electroluminescent Materials was reviewed and the structure features and related theory were introduced. 综述了近年来1,8-萘酰亚胺类小分子电致发光材料的研究进展,作了结构特点和相关理论的说明。
- The downtrend of H content is more evident than other elements, which shows the dissolution laws of small molecular phases in the process of fractional extraction. 元素含量减小趋势要比其它元素明显很多，其变化更能反映萃取后小分子相的溶出行为;
