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- AcSDKP can inhibit proliferation and collagen synthesis in cultured rat cardiac fibroblasts mediated by PDGF. AcSDKP对PDGF介导的心脏成纤维增殖和胶原合成均有明显抑制作用,这可能与其抗心脏纤维化的作用相关。
- AIM: To investigate the effects of matrine on the proliferation and collagen synthesis of rat cardiac fibroblasts(CFs) induced by aldosterone(Ald),to research the mechanism of regression of heart fibrosis. 目的：研究苦参碱(Matrine，Mat)对醛固酮(aldosterone，Ald)诱导新生大鼠心肌成纤维细胞(Cardiac Fibroblasts，CFs)增殖及胶原代谢的影响，探讨其抑制心肌纤维化的机制。
- Calcineurin Mediates the Proliferation of Rat Cardiac Fibroblasts Induced by Arginine Vasopressin 钙调神经磷酸酶调控精氨酸升压素诱导大鼠心脏成纤维细胞增殖的作用
- Calcineurin mediates the collagen synthesis of rat cardiac fibroblasts induced by arginine vasopressin 钙调神经磷酸酶调控血管升压素诱导大鼠心脏成纤维细胞胶原合成的作用
- Calcineurin signaling pathway involved in cultured rat cardiac fibroblasts proliferation 钙调神经磷酸信号通路参与心肌成纤维细胞的增殖
- Effects of arginine vasopressin on inducible nitric oxide synthase-nitric oxide system activity in cultured rat cardiac fibroblasts 精氨酸升压素对大鼠心肌成纤维细胞诱导型一氧化氮合酶-一氧化氮系统活性的影响
- Effects of Estradiol on the MMPs/TIMPs of Rat Cardiac Fibroblasts and Its Role in the Pathogenesis of Left Ventricular Hypertrophy Associated with Hypertension 雌二醇对大鼠心脏成纤维细胞MMPs/TIMPs的影响及其与高血压左室肥厚关系的研究
- rat cardiac fibroblasts 大鼠心肌成纤维细胞
- AcSDKP further increased MMP-2 and MMP-9 activity and MMP-1 expression of cardiac fibroblasts induced by 10% FBS and PDGF. AcSDKP能够进一步增加由10%25血清和PDGF诱导的心成纤维细胞MMP-2、MMP-9的活性,并促进MMP-1的表达。
- Objective: To investigate the effects of lysophosphatidic acid (LPA) on the proliferation and collagen synthesis of cardiac fibroblasts(CFs) in vitro culture. 目的观察溶血磷脂酸(LPA)对体外培养心脏成纤维细胞(CFs)的增殖与胶原合成的影响。
- Objective To investigate the effects of tetramethylpyrazine (TMP) on the proliferation and collagen synthesis of cardiac fibroblasts (CF) in vitro culture. 目的观察川芎嗪(TMP)对体外培养心脏成纤维细胞(CF)的增殖与胶原合成的影响。
- Myocardium collagen metabolic regulation involves intersitital cells major cardiac fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, and pericytes. 涉及心肌胶原代谢调控的间质细胞主要有成纤维细胞、肌成纤维细胞、平滑肌细胞、内皮细胞、周细胞等。
- In the present study, rat cardiac sarcoplasmic reticulum(SR) phospholamban (PLB) phosphatase was partially purified by chromatography on DEAE-Sephacel. 用DEAE－Sephacel层析法部分纯化了大鼠心肌肌浆网phospholamhan（PLB）蛋白磷酸酶（PPase），并证明其是PPase－1。
- Objective To introduce a rapid method of isolateing and culturing cardiac myocyte of neonatal rats and to compare the difference with cardiac fibroblast. 目的 探索一种快速分离和培养新生大鼠心肌细胞的方法，比较心肌细胞和成纤维细胞的形态差异。
- Object To investigate the action of safflower yellow (SY) against rat cardiac hypoxic damage and the effect on energy metabolism. 目的探讨红花黄色素(SY)缓解大鼠心肌缺氧性损伤作用及其对能量代谢的影响。
- The approach uses a fibrin gel to support rat cardiac cells temporarily, before the fibrin breaks down as the cells organize into tissue. 该方法利用纤维蛋白凝胶支持鼠类心肌细胞，随后纤维蛋白逐渐降解，心肌细胞整合到组织中。
- Simvastatin can inhibit the hypertrophy of cultured rat cardiac myocytes induced by serum,the mechanism of which might be related with the increase of PTEN expression. 辛伐他汀能够抑制血清诱导的心肌细胞肥大,升高PTEN表达水平可能是其分子生物学机制之一。
- Results: On the culture of 0.4% FBS,PDGF stimulated cardiac fibroblasts proliferation and collagen synthesis with a dose-dependent manner at the concentrations from 1 ng/ml to 20 ng/ml,in which 10 ng/ml PDGF reached its peak. 采用3H-脯氨酸掺入法检测心脏成纤维细胞胶原的合成。 结果:PDGF在1~20 ng/ml浓度范围内对心脏成纤维细胞增殖和胶原合成均有促进作用。
- HOH J F,McGRATH P A,HALE P T.Electrophoretic analysis of multiple forms of rat cardiac myosin:effect of hypothy sectony and throxine replacement[J].Mol Cell Cardial,1987,10:1052. 孟紫强;耿红.;二氧化硫吸入对小鼠心脏脂质过氧化和抗氧化指标的影响[J]
- Methods Cardiomyocytes and cardiac fibroblasts were isolated by trypsin digestion method. DNA and protein synthesis were measured by 3 H-deoxythy-midine( 3 H-TdR) and 3 H-Leucine( 3 H-Leu) incorporation. Protein content was measured by Bradford method. 方法采用体外乳鼠心肌细胞和心脏成纤维细胞培养,一定浓度的ET-1、ANP单独或联合作用细胞24h,以3H-胸腺嘧啶脱氧核苷(3H-TdR)、3H-亮氨酸(3H-Leu)掺入法测定细胞DNA、蛋白合成,Brad-ford法测细胞总蛋白含量,RT-PCR法测心肌细胞心钠素ANPmRNA的表达,评价ET-1、ANP对心肌细胞和成纤维细胞的作用。
