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- Aim To detect the hepatotoxic pyrrolizidine alkaloids ( HPA ) in the genus Ligularia Cass. 目的橐吾属植物中微量成分肝毒吡咯里西啶生物碱(HPA)的检测。
- Strychnine is used to kill rodents and pyrrolizidine alkaloids have significant activity against microbes. 而吡咯里西啶类生物碱则具有较强的杀菌活性。
- Pyrrolizidine alkaloids are a large class of natural products with hepatotoxicity and have been identified in more than 6 000 plant species. 摘要 吡咯里西啶生物碱广泛分布于6 000多种高等植物中,是一类肝毒性很强的天然产物。
- In the present paper, the advancement of research on the cytotoxicity and mechanism of pyrrolizidine alkaloids are reviewed. 本文对吡咯里西啶生物碱的细胞毒性及致毒机制的研究进展进行综述。
- Plants containing pyrrolizidine alkaloids were widely used in traditional medicine.Its hepatotoxicity is main toxicity as well known internationally. 含有吡咯里西啶生物碱的植物在传统医药中有广泛使用,其肝毒性引起广泛关注。
- Abstract: Pyrrolizidine alkaloids(PAs) are widely distributed in plantae.Many PAs are hepatotoxic,Lung toxicity(carcinogenesis),neurotoxic and cytotoxic. 摘 要: 吡咯里西啶生物碱广泛分布于植物界。
- Pyrrolizidine alkaloids are activated by metabolic activation in liver and their parent compounds are converted into active “pyrrole” which may produce hepatotoxicity. 吡咯里西啶生物碱在肝脏代谢成活性代谢物吡咯后产生肝毒性。
- In order to providing some foundation for the future studies,the advancement on the pharmacologic actions,toxicity,and pharmacokinetics or toxicokinetics of pyrrolizidine alkaloids was reviewed. 作者综述了吡咯里西啶生物碱的药理作用、毒性和药(毒)物代谢动力学等方面的研究进展,以便为后期研究提供基础。
- Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MS~n 橐吾属植物中肝毒吡咯里西啶生物碱的LC/MS~n检测
- Keywords Senecio;chemical constituents;pyrrolizidine alkaloids;heptatotoxic effect; 千里光属;化学成分;吡咯里西啶类生物碱;肝毒作用;
- Keywords Heptic veno-occlusive disease;TLC;Sedum aizoon;Pyrrolizidine alkaloids; 肝小静脉闭塞病;薄层层析;土三七;吡咯烷生物碱;
- Keywords pyrrolizidine alkaloids;hepatic veno-occlusive disease;plants;medicinal herbs; 吡咯里西啶类生物碱;肝小静脉闭塞病;植物;草药;
- Keywords Senecio scandens Buch.-Ham.;preliminary phytochemical test;chemical composition;pyrrolizidine alkaloid; 千里光;植物化学预试;化学成分;双稠吡咯啶生物碱;
- pyrrolizidine alkaloids (PAs) 吡咯里西啶生物碱
- pyrrolizidine alkaloids 双稠吡咯啶类生物碱, 吡咯里西啶类生物碱
- Pyrrolizidine alkaloids(PA) 吡咯里西啶生物碱
- Plant pyrrolizidine alkaloid 植物双稠吡咯啶类生物碱
- pyrrolizidine alkaloid 双苄基异喹啉类生物碱
- Studies on the alkaloids from Salsola collina Pall. 猪毛菜中生物碱化学成分的研究。
- Determination of Alkaloids in Portulaca Oleracea L. 马齿苋总生物碱的测定。