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- Via near infrared(NIR) spectroscopy combined with radial basis function neural network(RBFNN), a model for determining pyrazinamide(PZA) content in tablets was established. 采用近红外光谱技术结合径向基神经网络(RBF)建立测定吡嗪酰胺片中吡嗪酰胺含量的定量分析模型。
- The following two decades then witnessed the development of a series of anti-TB drugs including p-aminosalicylic acid (PAS), isonicotinyl hydrazide (INH), pyrazinamide (PZA), D-cycloserine (CS), Ethambutol (EMB), ethionamide (ETH) and rifampin (RIF). 随后的20年中,迅速发展出了一系列抗结核药物,包括对氨基水杨酸(PAS)、异烟肼(INH)、吡嗪酰胺(PZA)、环丝氨酸(CS)、乙胺丁醇(EMB)、利福平(RIF)等。
- CALYX globally ranks as the largest supplier of Pyrazinamide. 卡利克斯公司是世界公认的吡嗪酰胺的最大供应商。
- We hold COS and USDMF for Pyrazinamide and Zopiclone. 我们的吡嗪酰胺和佐匹克隆通过了COS和美国的DMF认证。
- They were treated with INH given in a dose 20 mg/kg/day,PZA 30 mg/kg/day andRFP 15 mg/kg/day by mouth once a day. 三药口服剂量是 INH20mg/kg/天,RFP15mg/kg/天、PZA30mg/kg/天,均为顿服。
- The most common anti-TB medicines are isoniazid, rifampicin, pyrazinamide, streptomycin and ethambutol. 最常见的抗结核药物是异烟肼、利福平、吡嗪酰胺、链霉素和乙胺丁醇。
- OBJECTIVE To observe the protective effect of Hugan Yifei pellet on hepatic injury induced by pyrazinamide. 目的:观察护肝益肺颗粒对吡嗪酰胺致肝损害小鼠的保护作用。
- Results Ethambutol hydrochloride, isoniazid, pyrazinamide and rifampicin all had good chromatographic behavior. 结果 盐酸乙胺丁醇、利福平、吡嗪酰胺和异烟肼均具有良好的色谱行为。
- Objective:To establish a method for determination of assay of Rifampin,Isoniazid,and Pyrazinamide Capsules and Tablets. 目的:建立异福酰胺胶囊及片的含量测定方法。
- Results: The incidence of drug-induced hepatitis was 17% when chemotherapy regimens contained INH,RFP and PZA were used,which needs our great attention. 结果:使用含INH、RFP、PZA抗痨药物的化疗方案时,药物性肝炎的发生率为17%25,应该引起我们医生的重视。
- The results sbowed that the gene mutation rate of PZA, SM, RFP,INH and EMB resistance in those clinically isolated strains was 42 7%,71 7%,78 9%,68 6% and 43 9%, respectively. 结果表明 ,耐吡嗪酰胺 (PZA)pncA基因 ,耐链霉素 (SM)rpsL基因 ,耐利福平 (REP)rpoB基因 ,耐异烟肼 (INH)katG基因 ,耐乙胺丁醇 (EMB)embB基因的突变率分别为 4 2 7%25 ,71 7%25 ,78 9%25 ,6 8 6%25 ,4 3 9%25。
- Methods An HPLC method was established to determine the contents of ethambutol hydrochloride, isoniazid, pyrazinamide and rifampicin in the Yianbiqinlifuyiyan tablets. 方法 采用高效液相色谱法测定乙胺吡嗪利福异烟片中盐酸乙胺丁醇、利福平、异烟肼和吡嗪酰胺的含量。
- Conclusion The HPLC method for the determination of ethambutol hydrochloride, isoniazid, pyrazinamide and rifampicin could be used for the quality control of Yianbiqinlifuyiyan Tablets. 结论 盐酸乙胺丁醇、利福平、异烟肼和吡嗪酰胺的高效液相色谱含量测定方法，可以用于制剂的质量控制。
- Conclusion The HPLC method for the determination of ethambutol hydrochloride, isoniazid, pyrazinamide and rifampicin could be used for the quality control of Yianbiqinlifuyiyan ... 结论盐酸乙胺丁醇、利福平、异烟肼和吡嗪酰胺的高效液相色谱含量测定方法,可以用于制剂的质量控制。
- Zwolska Z,Niemirowska-Mikulska H,Augustynowi_cz-Kopec E,et al.Bioavailability of rifampicin,isoniazid and pyrazinamide from fixed-dose combination capsules[J].Int J Tuberc Lung Dis,1998 ,2(10):824. 赵伟杰;段连山;李惠文;等.;抗结核固定剂量复合剂的人体相对生物利用度研究[J]
- pyrazinamide (PZA) 对二氮苯酰胺
- Myalgia of lower limbs induced by pyrazinamide 吡嗪酰胺致下肢肌肉痛
- Keywords RP-HPLC;ion-pair;Isoniazid;Pyrazinamide; 离子对;反相HPLC;异烟肼;吡嗪酰胺;
- Determination of pyrazinamide tablets by UV spectrophotometry 紫外分光光度法测定吡嗪酰胺片含量
- Keywords Pyrazinamide;gel;antituberculotic;intervention;security; 吡嗪酰胺;凝胶剂;抗结核药;介入;安全性;
