prolonged markedly the time of sleep in mice with the hypnotic effect induced by phenobarbital sodium, while SWNH (50 mg/kg), the natural calculus bovis (100 mg/kg), and the artificial calculus bovis (100 mg/kg) did not.

• 生物牛黄中间体100mg/kg体重、150mg/kg体重腹腔注射给药，可使苯巴比妥钠引起的小鼠睡眠时间明显延长；