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- Peptide deformylase (PDF) is an essential enzyme involving in bacterial protein biosynthesis. 肽脱甲酰基酶是细菌蛋白质合成过程中一种关键酶。
- This review summarizes the characteristics, crystal structure and function of peptide deformylase in bacteria. 肽脱甲酰化酶抑制剂具有广谱抗菌活性和很好的选择性。
- Objective:To develop lead compounds classified as a nonpeptide bacterial peptide deformylase (PDF) inhibitor. 目的:发现新的肽脱甲酰基酶(PDF)抑制剂先导化合物。
- The peptide deformylase inhibitors (PDFIs) block the growth, metabolism and multiplication of bacteria, potentiating a novel type of antibacterial agent. 肽脱甲酰基酶抑制剂通过作用于该酶,影响细菌正常的生长、代谢和繁殖,从而可能成为一类新型抗菌药物。
- Aim To design and synthesize a series of N-formylhydroxylamine derivatives as peptide deformylase inhibitors and evaluate their antibacterial activities in vitro primarily. 摘要目的设计合成N-甲酰羟胺类肽去甲酰酶抑制剂，初步评价其体外抗菌活性。
- And the overexpressed and soluble peptide deformylase was gained.The enzyme was purified from the overexpressed E.coli cells and had strong enzymatic activity. 从宿主细胞中提取分离该酶，并进行酶活性检测，诱导表达的肽脱甲酰基酶有很高的酶活性。
- Keywords Peptide deformylase Target Enterococcus Faecium; 肽脱甲酰基酶;靶点;肠球菌;
- Keywords Helicobacter pylori;Peptide deformylase;Target; 幽门螺杆菌;肽脱甲酰基酶;药物靶位;
- Keywords Peptide deformylase;High throughput screen model;Actinonin; 肽脱甲酰基酶;高通量筛选模型;放线酰胺素;
- Keywords peptide deformylase;inhibitor;synthesis;bacteriostasis activity; 肽脱甲酰化酶;抑制剂;合成;抑菌活性;
- Keywords peptide deformylase;inhibitors;structure-activity relationship; 肽脱甲酰化酶;抑制剂;构效关系;
- Soluble Expression of Helicobacter pylori Peptide Deformylase in E. Coli and its Activity Determination 幽门螺杆菌肽脱甲酰基酶基因在大肠杆菌中的可溶性表达与活性检测
- The Peptide Deformylase of Enterococcus faecium Overexpressed in E.coli BL21(DE3) and the Enzymatic Activity Assay 肠球菌肽脱甲酰基酶在大肠杆菌BL21(DE3)中高效表达及其活性检测
- Keywords Peptide deformylase;Inhibitor;Molecular dock;Peptidomimetics;Actinonin;Synthesis; 肽脱甲酰化酶;抑制剂;分子对接;模拟肽;放线酰胺素;合成;
- Keywords isoxazole-contained 2-n-pentyl succinate hydroxamate;peptide deformylase inhibitor;antibacterial activity; 异（口恶）唑;丁二酰异羟肟酸衍生物;肽脱甲酰基酶抑制剂;抗菌活性;
- Keywords peptide deformylase;inhibitor;oxazolidinone;antibacterial;protein synthesis;review; 肽脱甲酰基酶;抑制剂;恶唑烷酮;抗菌剂;蛋白质合成;综述;
- Keywords PDF（Peptide Deformylase）;molecular docking;molecular dynamics;density functional theory; PDF（肽脱甲酰基酶）;分子对接;分子动力学模拟;密度泛函理论;
- Keywords peptide deformylase;peptide deformylase inhibitor;structure-activity relationship;antibacterial agent; 关键词肽脱甲酰基酶;肽脱甲酰基酶抑制剂;构效关系;抗菌药物;
- Keywords peptide deformylase;broad spectrum antibiotics;antibacterial drug target; 肽脱甲酰基酶;广谱抗生素;抗菌药物筛选靶点;
- Keywords Helicobacter pylori;Peptide deformylase;gene expression;gene amplification;actiuity determination; 幽门螺杆菌;肽脱甲酰基酶;基因表达;基因扩增;活性检测;
