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- ATF-2,one of substrates of p38 MAPK,mediated iNOS gene transcription induced by p38 MAPK. p38 MAPK底物转录因子ATFZ,介导了 p38 MAPK对rOS启动子的转录
- Vincristine could affect the activity of p38 MAPK in gastric cancer cell SGC7901 and multidrug resistant cell SGC7901/VCR. p38MAPK信号转导途径可能与长春新碱的抗肿瘤活性相关 ,肿瘤细胞内 p38MAPK对长春新碱刺激的反应速度可能与胃癌长春新碱耐药相关
- Objective To study the effect of gastrin on the mRNA and protein expression of urokinase-type plasminogen activator (u-PA) in human colon cancer cells and detect the role of p38 MAPK in this process. 目的研究胃泌素对人结肠癌细胞尿激酶型纤溶酶原激活物(u-PA)mRNA和蛋白表达的影响,探讨信号分子p38 MAPK在其中的作用。
- METHODS: We used immunohistochemical ABC and Western blot method to detect the expression of p38 MAPK in lung tissues and airway epithelial cells in acute lung injury rat model and observed the influence of N acetylcysteine (NAC) on the expression. 方法 :采用免疫组织化学ABC法和Western blot技术 ;检测磷酸化的 p38MAPK在大鼠急性肺损伤模型气道和肺组织的表达 ;并同时观察N 乙酰半胱氨酸 (NAC)对其表达的影响 .
- Study of Recipe of DangGui BuXue Decoction on ox-LDL Activating p38 MAPK of Monocyte 当归补血汤对ox-LDL激活单核细胞p38MAPK的作用研究
- The role of p38 MAPK in LPS-induced ICAM-1 expression of vascular endothelial cells p38MAPK在LPS诱导血管内皮细胞ICAM-1表达中的作用
- P38 MAPK, PKC and PI3-K Mediate NADPH Oxidase Activation and Phagocytosis in Bovine PMN 牛多形核白细胞(PMN)中P38 MAPK,PKC和PI3-K介导的NADPH氧化酶激活和吞噬作用(英文)
- The Change of p38 MAPK Activation and the Effect on Morphology and Electrical Physiology in Rat Hippocampal Neuron Following Kainic Acid Administration 红藻氨酸对大鼠海马p38MAPK活性及海马神经细胞形态和电生理的影响
- p38 MAPK pathway p38MAPK通路
- p38γ MAPK protein p38γMAPK蛋白
- p38 MAPK p38丝裂原活化蛋白激酶
- 44 Spaziani A, Alisi A, Sanna D, Balsano C.Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1.J Biol Chem 2006; 45李波;冯德云;程瑞雪;何琼琼;胡忠良;郑晖;文继舫.;丙型肝炎病毒核心蛋白对人源肝细胞生物学行为的影响
- CCK activates MAPK in pancreatic acinar cells. 在胰腺腺泡细胞CCK可激活MAPK。
- Activation of p38 in PIN is significantly higher than in BPH. PIN组织中p38的活性显著高于BPH。
- MAPK pathway minimally consists of a MAPKKK-MAPKK-MAPK module. MAPK讯息传递路径主要藉由MAPKKK-MAPKK-MAPK模式所引发下游的级联反应。
- So MAPK can serves as a molecular target for diseases treatment. 因此,MAPK是潜在的治疗分子靶。
- PTP is a negative regulating factor in the MAPK pathway. MAPK级联途径参与有机体的发育、细胞增殖、激素调节以及逆境胁迫的信号转导, PTP在MAPK级联途径中主要起负调控作用。
- AIM:To investigate the expression of phosphorylated/activated P38 mitogen-activated protein kinase(MAPK)and the apoptosis of retinal cells in rat retina after partial optic nerve crush. 目的:动态观察视神经损伤后视网膜中P38丝裂原活化蛋白激酶(MAPK)活性的表达变化和早期细胞凋亡情况。
- The expression of Gap-43 and P38 mRNA related to neural plasticity becomes active in post IR penumbra region. 结论:与神经重塑有关的Gap-43和P38mRNA在局部脑缺血再灌注后缺血半影区的表达十分活跃。
- VES had no effects on p38 and ATF-2. Antisense to ATF-2 oligomers also had no effect on VES-mediated apoptotic rate. VES 并不改变p38 蛋白的表达,且其下游转录因子ATF-2 的表达未发生改变,转染ATF-2反义寡聚核苷酸后VES 诱导的细胞凋亡亦未发生改变。