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- p16 p15 gene p16、p15抑癌基因
- P15 gene methylation might be related with the pathogenesis, and prognosis of MM. p15基因甲基化可能是MM发病的原因之一,与MM的发展及预后有一定的关系。
- Objective:To explore the role ofinactivation of P15 gene by means of hypermethylation in the pathogenesis of MDS. 目的:研究P15基因通过甲基化失活在骨髓增生异常综合征(MDS)发病中的作用。
- The existence of exogenous p15 gene eDNA and the expression of P15 protein were assayed by PCR and Western blotting,respectively. PCR检测外源p15基因cDNA,Western印迹法检测转染细胞P15蛋白的表达。
- Method:P15 gene methylation from 33 cases of MM and 20 of controls was investigated with methylation-spectific PCR(MSP) methods. 方法:采用甲基化特异性聚合酶链反应(MSP)研究33例多发性骨髓瘤(MM)及20例对照组的p15基因甲基化情况。
- Objective To detect the alterations of k-ras gene and p15 gene and analyse the genomic instability in the malignant process of 16HBE cells induced by crystalline nickel sulfide(NiS). 目的 检测结晶型硫化镍 (NiS)对K -ras基因和P15基因的改变及基因组不稳定性的影响 ,从而进一步探讨镍化合物致癌的分子机制。
- Peripheral blood mononuclear cell(MNCs)from healthy volunteer,HL-60,HepG2,293,HeLa,SGC7901,U266 and CEM were unmethylated; and K562,NB4,GMC,Jurkat seemed to have deletion or mutation of p15 gene. 正常人单个核细胞、HL-60、HeLa、HepG2、293、SGC7901、U266、CEM细胞则为p15非甲基化,而K562、NB4、GMC、Jurkat似乎显现p15基因缺失或突变。
- It is concluded that the imatinib in combination with the expression of p15 gene has a synergistic effect on the inhibition of K562 cell proliferation and promotion of its apoptosis. 结论:表达外源P15蛋白联合应用伊马替尼对抑制K562细胞增殖及促凋亡方面具有协同作用。
- Keywords p16 p15 pRb Neoplasma Epidermis Immunohistochemical staining; 表皮肿瘤;免疫组化染色;
- 5'-GpG islands of p15 gene hypermethlation in non-Hodgkin's lymphomas 非何杰金淋巴瘤p15基因操纵区5’-CpG岛的甲基化的研究
- Study on the methylation of p15 gene CpG islands in acute leukemia: using methylation specific PCR method 采用甲基化特异性聚合酶链反应研究急性白血病p15基因CpG岛甲基化
- AIM To explore the molecular changes in genes p15 INK4b and p16 INK4a associated with cyclophosphamide(CP) and thiotepa(TEPA) mediated carcinogenesis. 目的 了解环磷酰胺 (CP)和塞替哌 (TEPA)诱导永生化人支气管上皮细胞 (BEAS 2B)的恶性转化株内BEAS CP和BEAS TE细胞p16和p15基因的突变情况。
- Transmissibility Of p15 gene expression and inhibitory effect of 5-Aza2-cdR on proliferation of Raji cell lines 5-Aza2-cdR诱导Raji细胞p15基因再表达及细胞生长抑制遗传性的实验研究
- The frequency of P53,P15 and P16 alteration Was 37.3%,11.9% adn 23.8% respectively and only one case with benign respiratory disease showed P16 homozygous deletion. 肺癌组织中P5 3、P15、P16基因改变频率分别为 37.;3%25、11
- Methods The expressions of p16,p15 and pRb in 34 BCCs,12 keratoacanthomas,11 seborrheic keratoses and 10 normal skin specimens were detected by S-P immunohistochemical staining. 方法用S-P免疫组化染色法检测34例基底细胞癌(BCC),12例角化棘皮瘤(KA),11例脂溢性角化病及10例正常皮肤中p16,p15及pRb蛋白的表达。
- Method:The expression of P16 and P15 protein in 46 cases of gastric carcinoma and 69 metastatic lymph node were detected by SP immunohistochemical method. 方法:采用链霉菌抗生物素蛋白过氧化物酶连接法(SP法),检测46件胃癌组织及69件转移淋巴结标本中P16、P15蛋白的表达。
- The position that a given gene occupies on a chromosome. 基因座在一条染色体上某种给定基因所占的位置
- Half of the people who inherit the gene express it. 半数有这种遗传基因的人，皆显示出其影响
- To investigate the role of p16 gene aberrant alteration in pathogenesis and progression of human larynx carcinoma. 目的：探讨p16基因的缺失与人喉癌的发生、发展的关系。
- However, the transcription level of p16 INK4A gene could not be associated with DNMT1 in SW1116 cell. 各组细胞p16 INK4A基因的表达差异不明显。
