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- 目的:通过研究内皮素-1(endothelin-1,ET-1)在口腔粘膜下纤维化中mRNA的表达,探讨ET-1与OSF(oral submucous fibrosis)病变发生发展的关系。Objective: To study the expression of endothelin-1 (ET-1) in oral submucous fibrosis(OSF), so as to investigate its role in the pathogenesis of OSF.
- 目的:探讨丹参是否能够通过改善槟榔损伤的血管内皮细胞(endothelial cell,EC)的功能而对口腔黏膜下纤维性变(oral submucous fibrosis,OSF)产生治疗作用。PURPOSE: To discuss the mechanism of salvia miltiorrhizae injection (SMI)on oral submucous fibrosis (OSF) through improving the function of the vascular endothelial cell (EC) damaged by aqueous areca nut extract (AANE).
- 口腔癌缺失(deleted in oral cancer-1,DOC-1)基因是Todd等于1995年利用仓鼠口腔癌模型分离和证实的一个候选抑癌基因，p12蛋白是其编码的具有肿瘤生长抑制功能的蛋白。Deleted in oral cancer-1 (DOC-1) is a novel putative oral tumor suppressor genes identified and isolated from the hamster oral cancer model in 1995, p12 protein is a tumor growth suppressor coded by DOC-1. As a new candidate tumor suppress gene, up to the present its some functions and mechanisms have been studied.
- 尽管采用了以外科手术切除为主,协同运用化疗或放疗手段的综合治疗,但口腔鳞癌(Oral Squamous Cell Carcinoma, OSCC)患者的总体生存率并无显著提高,尤其是临床中、晚期患者,其疗效仍不理想。Despit of comprehensive treatments with primary surgery integrated with chemiotherapy or radiotherapy, the survival rate of the patients with Oral Squamous Cell Carcinoma(OSCC) has not been improved evidently, especially advanced OSCC. Dendritic cells (DCs), which are uniquely the most potent professional antigens-presenting cells(APCs) with the capacity to activate naive T lymphocytes, are considered to be promising adjuvants for immunity against cancer.
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