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- Mechanism of Action: Stavudine, a nucleoside analogue of thymidine, inhibits the replication of HIV in human cells in vitro. 司他夫定是胸苷核苷类似物，可抑制HIV病毒在人体细胞内的复制。
- Lamivudine (LAM) is a nucleoside analogue widely used for the treatment of chronic hepatitis B virus (HBV) infection. 拉米夫定是一种核苷类似物，被广泛应用于治疗慢性乙肝。
- Lamiudine (LAM) is a nucleoside analogue widely used for the treatment of chronic hepatitis B irus (HB) infection. 拉米夫定是一种核苷类似物，被广泛应用于治疗慢性乙肝。
- The first drug approved for use against HIV, zidovudine (AZT), is a nucleoside analogue as well. 第一个上市对抗HIV的药物是叠氮胸苷（AZT），也是核苷的类似物。
- Lamivudine, a nucleoside analogue, has been used in China since 1998, which has brought new hope to the Hepatitis B patients. 摘要核苷类似物拉米夫定于1998年在我国上市，为乙型肝炎的抗病毒治疗带来了新的希望。
- The nucleoside analogue that is registered for use in hepatitis B patients in Hong Kong, Mainland China and the United States of America is lamivudine. 核苷类似物(拉米)在香港大陆和美国被用于乙肝病人。
- Long-term treatment with the second-generation nucleoside analogue lamivudine (lam) efficiently inhibits HBV replication with frequent viral polymerase mutations. 二代拉米夫定的长期应用可以有效地抑制病毒多聚酶突变频繁的HBV发生复制。
- These strategies have yet to be optimized for hepatitis B, but may include multiple therapies such as immune-based therapies in combination with one or more nucleoside analogue treatments. 这些策略应使乙肝治疗最佳化，可能包括多种治疗，如基于免疫的治疗与一个或多个核苷类似物联合应用。
- Isonucleosides represent a new class of nucleoside analogues. 异核苷代表了一类新的核苷类似物。
- Keywords Nucleoside analogue;Pyrrolidone;Uracil; 核苷类似物;吡咯烷酮;尿嘧啶;
- T-cell selective nucleoside analogue T细胞选择性核苷类似物
- Nucleoside analogues have attracted more and more attention as their outstanding antiviral and anticancer bioactivity. 摘要核苷类化合物由于其显著的抗病毒、抗癌等生理活性而受到广泛关注。
- De novo combination therapy with peginterferon and nucleoside analogues should also be studied I think. 对于聚乙二醇干扰素与核苷类似物的联合初始治疗也是需要进一步研究。
- Nucleoside analogues are currently the main drug therapy against HBV infection.However, this type of therapy can cause gene mutations in HBV that result in drug resistance. 核苷类药物是目前抗乙型肝炎病毒(HBV)的主要药物,但它可引起HBV基因的变异,从而引起耐药。
- It is linked to nucleoside analogues (a class of drugs that prevent healthy cells from becoming infected with HIV), although the condition may occur more commonly with Stavudine. 它常与核苷类药物（一种可阻止健康细胞转化为感染艾滋病毒细胞的药物）联系在一起，尽管如此，这种疾病的产生与司他夫定联系在一起的几率更大。
- Viral dynamic studies showed more rapid decline of serum HBV-DNA and eventually viral eradication in combination therapy of two different nucleoside analogues. 病毒动力学研究表明：通过两种不同的核苷类似物联合治疗，血清中的HBV-DNA含量会快速下降，最终彻底消除。
- But studies of reverse transcriptase, informed by knowledge of the enzyme's gene sequence, have enabled drug developers to introduce less toxic nucleoside analogues. 不过继续研究反转录酶的基因序列，已经发展出毒性比较弱的核苷类似物，拉美夫锭（lamivudine）正是其中的一种。
- I am optimistic this will happen but we first need data from clinical trials to establish the usefulness of nucleoside analogues in decompensated cirrhosis. 但是我们需要临床试验的数据支持核苷类似物在失代偿肝硬化中的有效性。
- Lamivudine, and most nucleoside analogues, acts by suppression of viral replication through competitive inhibition of reverse transcriptase and DNA polymerase. 拉米还有大多数的核苷类似物，通过竞争性地阻断翻转录酶和DNA聚合酶来抑制病毒复制。
- Current options to treat chronic HBV infection are restricted to the use of interferon (IFN) alfa and nucleoside analogues such as lamivudine or adefovir, but these treatments have some... 由HBV持续感染所引起的病毒性肝炎、肝硬化和肝癌等已成为严重危害人民生命健康的疾病。
