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- OBJECTIVE To synthesize Tropisetron hydrochloride and optimize the process. 目的合成盐酸托烷司琼并改进其合成工艺。
- METHODS Tropisetron hydrochloride was synthesized by steps of chlorination, esterification, and hydrochlorination. 方法以3-吲哚甲酸为起始原料,经氯代、酯化、成盐酸反应制得长烷司琼。
- The tropisetron hydrochloride capsules were prepared by different methods with starch as main excipient. 以淀粉为主要填充剂,采用不同工艺制备盐酸托烷司琼胶囊。
- The tropisetron hydrochloride content was determined by HPLC, and the percentage of dissolution was evaluated. 用高效液相色谱法测定其含量,小杯法测定胶囊体外溶出度。
- Objective:To investigate efficacy of Tropisetron on nausea and vomiting caused by breast cancer chemotherapy. 目的:观察托烷司琼在预防乳腺癌化疗所致恶心呕吐的临床疗效。
- Conclusion Tropisetron hydrochloride and sodium chloride injection is safe and effective on nausea and vomiting induced by chemotherapy. 结论盐酸托烷司琼氯化钠注射液治疗化疗药物所致恶心、吐安全有效。
- Tropisetron Hydrochloride was synthesized from 1H-indol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol. 摘要以3-吲哚甲酸为起始原料,经氯化亚砜酰氯化、与托品醇缩合合成了托烷司琼盐酸盐。
- RESULTS Chemical structure of Tropisetron hydrochloride was confirmed by element analysis,UV,IR, 1HNMR, ESI-MS and EI etc. 结果所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。
- Objective: To compare the clinical effect and safety of Tropisetron with Granisetron in the prevention of nausea and vomiting induced by anti-cancer drugs. 摘要目的:观察国产盐酸托烷司琼胶囊预防化疗所致恶心呕吐的临床疗效和安全性,同时选用格拉司琼胶囊作对照组进行分析。
- Objective To compare and observe the effects of Tropisetron Mesylate (TM) and Metoclopramide (M) in the prevention of chemotherapy-induced digestive side effects. 摘要目的对比观察甲磺酸托烷司琼与甲氧氯普胺两组药物控制化疗引起的胃肠道反应的疗效及其不良反应。
- Conclusion Preoperatively administered tropisetron before tramadol loading dose can effectively reduce the incidence of PONV via the reduction of plasma motilin. 结论曲马多负荷量术前给予托烷司琼能使血清胃动素的水平下降,从而更有效地预防恶心、呕吐。
- Keywords Navoban Breast cancer Emesis Nausea; 关键词欧必亭;乳腺癌;呕吐;恶心;
- Conclusions Tropisetron Mesylate was a new and safety antiemetic drug, which can prevent digestive side effect effectively, and the control of acute emesis was superior to that of meoclopramide. 结论甲磺酸托烷司琼是一种新的安全的止吐药,能有效预防化疗所致的胃肠道反应,尤其对急性呕吐的控制显著优于甲氧氯普胺。
- OBJECTIVE: To evaluate the preventive efficacy of highly selective 5-HT3 receptor antagonist tropisetron for postoperative nausea and vomiting(PONV) in patients undergoing neurosurgery craniotomy. 目的:评价高选择性5-羟色胺(5-HT3)受体拮抗剂托烷司琼对神经外科术后患者出现的恶心、呕吐的预防作用。
- Keywords Anti-neoplastic combined chemotherapy protocols;Nausea/prevention and control;Vomiting/prevention and control;Tropisetron hydrochloride;Navoban; 抗肿瘤联合化疗方案;恶心/预防和控制;呕吐/预防和控制;盐酸托烷司琼;欧必亭;
- Keywords Navoban Ondansetron Cisplatin Emesis/Prevent and control; 欧必亭;枢丹;顺铂;呕吐/预防和控制;
- Keywords PCA;Fentanyl;Navoban;Metoclopramide;Ondanesetron; 芬太尼;欧必亭;甲氧氯普胺;恩丹西酮;
- Synthesis of antiemetic Tropisetron hydrochloride 止吐药盐酸托烷司琼的合成
- Keywords Tropisetron;Carcinoma;Chemotherapy;Emesis; 托烷司琼;癌症;化学治疗;呕吐;
- Tropisetron Hydrochloride Tablets 盐酸托烷司琼片