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- missense oligodeoxynucleotide 错配寡脱氧核苷酸
- It is a missense mutation in exon III. 它是位于外显子III的错义突变。
- Two missense mutations were previously reported in CCD patients. 2个错义突变曾经报道过。
- Objective To study the immunotherapy role of CpG ODN(CpG oligodeoxynucleotide)on tumor. 目的探讨合成含CpG基序的寡核苷酸(CpG ODN)在肿瘤免疫治疗中的研究。
- Methods Phosphorothioate oligodeoxynucleotide containing 2 CpG motifs was synthesized as the adjuvant of HBsAg. 方法以血源HBsAg为接种疫苗,人工合成含CpG基序的硫代磷酸寡脱氧核苷酸作为佐剂,以BALB/e小鼠作为实验动物进行免疫接种;
- Both frameshift and missense mutations can be suppressed by intragenic suppressors. 移码突变和异义突变都能被基因内抑制基因所抑制。
- PURPOSE To investigate the effects of bcr3/abl2 anisense oligodeoxynucleotide (ASO) on chronic myeloid leukemia (CML). 目的 探讨癌基因bcr_3/abl_2反义寡核苷酸(antisense oligodeoxynucleotide;ASO)对慢性髓细胞白血病(CML)的作用及其作用机理.
- The missense mutation between adr NC-1 and adw or ayw is higher than between the different strains of adr. 不同亚型间的错义突变比同一亚型不同毒株间的错义突变多。
- The antisense drug synthesized by DNA synthesizer is an oligodeoxynucleotide (ODN). 由机器合成的反义核酸药物需要有效的纯度鉴定方法。
- Conclusion The missense mutation of LPL may play a key role in the decrease of LPL activity. 结论LPL基因在该位置的突变可能是导致患者LPL活性显著降低和血清甘油三酯增高的原因。
- Antisense oligodeoxynucleotide technique was used to observe the role of CLC-3 in the effect of ET-1 on BCECs. 采用反义核酸技术,观察CLC-3基因在ET-1对体外培养牛角膜内皮细胞影响中的作用。
- In ten patients, molecular studies revealed six novel missense mutations and three previously reported changes in GFAP. 十位患者分子水平的研究揭示神经胶质酸性蛋白有六个异常的错义突变和三个先前已报道的改变。
- Conclusion T313M missense mutation of PINK1 gene is rare in Chinese sporadic patients with PD. 结论PINK1基因T313M错义突变不大可能是中国散发性帕金森病患者的突变热点。
- There was only one missense mutation out of 5 mutation sites which led to the shift between leu and val amino. 5个变异位点中仅有1个为错义突变,导致亮氨酸和缬氨酸的转换,但该突变在牛种中分布有差异。
- OPC colum provides a high effciency,quick and convenient method for the purification of antisense phosphorothioate Oligodeoxynucleotide to Bcl 2. Bcl- 2硫代反义核酸 OPC纯化法是一种高效、快速、简便的方法
- Myocilin Ser341Pro missense mutation has not been reported before, so it may be a novel disease-causing mutation. 4. 3.;MYOC/TIGR基因Ser341Pro错义突变经检索未见报道,可能为一种新的致病性突变;4
- Objective: To investigate the adjuvant effects of CpG motif-containing oligodeoxynucleotide (CpG) in vitro on human esophageal cancer vaccine. 目的:探讨CpG基序在人食管癌Eca-109细胞疫苗研究中的佐剂效应。
- DNA damage caused by many factors may lead to missense mutation,deletion or illegal recombination. 多种因素可以引起DNA损伤而最终导致基因产生错义突变、缺失或错误重组。
- To study the effect of antisense focal adhesion kinase (FAK) oligodeoxynucleotide on the biological behaviors of U251 MG cells. 目的探讨反义黏着斑激酶(FAK)对U251人胶质瘤细胞株生物学行为影响。
- DNA damage caused by many factors may lead to missense mutation, deletion or illegal recombination. 摘要多种因素可以引起DNA损伤而最终导致基因产生错义突变、缺失或错误重组。