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- metanephric blastema [医] 后肾胚基
- Objective:To investigate the causes of misdiagnosis of metanephric adenoma(MA). 目的:探讨后肾腺瘤误诊原因。
- Methods: To report two cases of metanephric adenoma and review the literatures. 方法:观察2例后肾腺瘤大体形态,并进行光镜观察和免疫组化检测,随访患者并复习文献。
- They found that salamander regeneration begins when a clump of cells called a blastema forms at the tip of a lost limb. 他们发现,蝾螈再生是从一团被称为芽基的细胞在断肢顶端形成的时候开始的。
- But if we carefully deviated a nerve to the wound site, we could induce those fibroblasts to form a blastema instead. 但如果我们小心地将一条神经转向受伤的地方,我们就可诱导那些纤维母细胞形成芽基。
- Tanaka next hopes to decipher the genetic instructions governing blastema formation. 塔纳卡接下来希望破译控制芽基形成的基因指令。
- Immunohistochemially, with WT1, CD57, CK7, AE1, CD56 can help diagnosing metanephric adenoma. 文献报告WT1,CD57,CK7,AE1,CD56等抗体有助于鉴别诊断;
- From the blastema come skin, muscle, bone, blood vessels and neurons, ultimately growing into a limb virtually identical to the old one. 皮肤、肌肉、血管和神经元从芽基中长出来,最终生长成为和原来肢体几乎一模一样的新肢体。
- Objective: To explore the clinical features and histopathological character of metanephric adenoma. 摘要目的:探讨后肾腺瘤的临床及病理特点。
- Blastema in WT consists of sheets of densely packed small blue cells with hyperchromatic nuclei, little cytoplasm and conspicuous mitotic actiity. 后肾胚芽由密集排列的片状小蓝色的细胞构成,核染色质粗糙,胞浆稀少,有丝分裂像明显。
- Metanephric adenoma is a unique renal tumor with benign biologic behaior in spite of their large size. 后肾腺瘤尽管体积较大,但却为胚胎发育过程中后肾来源的良性肿瘤,较少见。
- It seemed, therefore, that all scientists needed to do was figure out how to induce an amputated limb to form a blastema. 因此科学家的目标,就是找出如何诱导断肢形成芽基的方法。
- Methods Pieces of rat metanephric tissue were explanted into plastic flask, and cells were grown in the tissue pieces. 方法 采用胚胎后肾组织块接种培养法。
- Metanephric adenoma is a unique renal tumor with benign biologic behavior in spite of their large size. 后肾腺瘤尽管体积较大,但却为胚胎发育过程中后肾来源的良性肿瘤,较少见。
- Objective: To investigate the causes of misdiagnosis of metanephric adenoma (MA). 摘要目的:探讨后肾腺瘤误诊原因。
- Bodies might find it easier to accept cells that have been only partially reprogrammed, like those in the axolotl’s blastema, than embryonic or fully reprogrammed cells. 与胚胎细胞或者完全基因重组的细胞相比,身体可能更容易接受经过部分基因重组的像美西螈芽基里那些细胞一样的细胞。
- If we succeed in generating a blastema in a mammal, the next big hurdle for us would be coaxing the site of a digit amputation to regenerate the entire digit. 如果我们能在哺乳动物身上成功产生芽基,接下来最大的挑战将是诱骗脚趾截断处长出完整的脚趾。
- We hope that this line of investigation will also reveal whether, as we suspect, the blastema itself provides critical signaling that prevents fibrosis in the wound site. 我们希望这条研究路线还能澄清我们的怀疑:芽基本身可能提供了重要的信号,来防止伤口纤维化。
- Objective To establish a method culturing metanephric mesenchymal cells(MMCs) primarily derived from metanephric tissue of embryonic rats in vitro. 摘要 目的 建立大鼠后肾间充质细胞(MMC)的培养方法,为体外研究肾脏纤维化的发病机制和防治提供细胞技术平台。
- Conclusion Cultured mesenchymal cells from metanephric tissue of embryonic rats can be propagated and have strong proliferation ability and stability. 结论 原代培养的细胞为间充质细胞并且可以传代,具备较强的细胞增殖能力和表型稳定性,为后续实验提供了可靠资源。