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- Memantine hydrochloride was synthesized from 1,3 dimethyladamantane by bromination, acetamidation with acetonitrile in sulfuric acid and hydrolysis with an overall yield of 67.8%. 以1;3-二甲基金刚烷为原料;经溴化、乙腈和硫酸的作用下乙酰胺基化、水解、成盐等反应及改进的后处理方法得到盐酸美金刚;总收率67.;8%25。
- Memantine Hydrochloride is developed by German and comes into market, in China, which belongs to new drug of third classification at the phase of development. 盐酸美金刚由德国研制上市，国内处于新药研发阶段，属国家三类新药。
- The project is of anti-risk ability, after the construction, the new formulations of Memantine Hydrochloride can be developed according to the markets, so which is better economic and social benefit. 该项目抗风险能力很强，项目建成后，可满足后续开发盐酸美金刚新剂型的需要，具有较好的经济效益和社会效益。
- Keywords memantine hydrochloride alzheimer agent synthesis; 盐酸美金刚胺;痴呆症治疗药物;合成;
- Keywords memantine hydrochloride;bromination;hydrolysis;optimization; 盐酸美金刚胺;溴代;水解;优化;
- Keywords NMDA acceptor antagonist;memantine hydrochloride;drug synthesis; NMDA受体拮抗剂;盐酸美金刚胺;药物合成;
- Keywords Colormetric method;Memantine hydrochloride;Content determination; 盐酸美金刚;比色法;含量测定;
- Keywords memantine hydrochloride;NMDA receptor antagonist;antidementia agent;synthesis; 盐酸美金刚;NMDA受体拮抗剂;痴呆症治疗药;合成;
- Keywords memantine hydrochloride;Alzheimer s disease;NMDA receptor antagonist;learning memory; 盐酸美金刚;阿尔茨海默病;NMDA受体阻滞剂;学习记忆;
- memantine hydrochloride 盐酸美金刚胺
- Dopamine Hydrochloride and Dextrose Inj. 盐酸多巴胺葡萄糖注射液。
- Lidocaine Hydrochloride and Epinephrine Inj. 酸盐利多卡因肾上腺素注射液。
- A trademark used for propoxyphene hydrochloride. 达尔丰用来表示丙氧基氢化物的商标
- Objective To synthesis Sotalol hydrochloride. 合成盐酸索他洛尔。
- Conclusion Memantine will affect liver and brain of neonatal rats. 结论美金胺对新生大鼠的脑和肝脏影响较大。
- Objective:To synthesize bambuterol hydrochloride. 目的:合成盐酸班布特罗。
- Dachuanxiong Hydrochloride for Injection. 注射用大川芎
- OBJECTIVE To synthesize palonosetron hydrochloride. 目的合成盐酸帕洛诺司琼。
- Ethylmorphine hydrochloride - reference spectrum? E2300000 盐酸乙基???
- Of the 44 patients, 50% also received adjunctive therapy with memantine. 其中50%25也接受美金刚的辅助治疗。
