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- Study on loss of heterozygosity of DCC in primary gastric carcinoma. 原发性胃癌中DCC抑癌基因杂合性丢失的研究
- A study on the loss of heterozygosity at 17p13.3 and abnormal expression of p53 protein in gastric carcinoma. 胃癌组织17p13.;3杂合性丢失及p53蛋白异常表达的研究
- Loss of heterozygosity at different chromosomes in pa-tients with breast cancer. 乳腺癌病人不同染色体位点上杂合缺失的研究
- In addition, 36.4% (8/22) of prostatic tumor tissues had loss of heterozygosity of GNMT gene. 此外,摄护腺癌组织GNMT基因有36.;4%25 (8/22)异合性丧失的情形;
- Methods The loss of heterozygosity (LOH)of YNZ22, APC, MCC and DCC genes was examined by PCR RFLP technique in 60 IM cases. 方法 应用PCR?RFLP法检测了60 例肠化生组织中YNZ22、APC 、MCC、DCC基因杂合性缺失现象。
- Objective To evaluate the loss of heterozygosity (LOH) and microsatellite instability (MSI) in the early diagnosis of bladder cancer. 目的探讨染色体微卫星不稳定性(MSI)及杂合性丢失(LOH)在膀胱癌早期诊断中的意义。
- In conclusion, the Lanyu pig is a unique breed without gene introgression from exotic pig breeds, but it had sustained loss of heterozygosity. 综合以上之结果,推论保种兰屿猪与以上6个台湾外来猪种间发生基因交流之可能性低为一独特之族群,但此族群可能因近亲配种致其基因多型性流失。
- Thirteen (2/15) percent of acute leukemia patients had loss of heterozygosity (LOH);the rate was higher than that in other leukemia types. 15例急性白血病中2例有LOH,比其他白血病发生率高。
- It was found that loss of heterozygosity(LOH) at MCC,LOH of DCC and LOH of YNZ22 loci were detected in 34.8%,36.0%and 43.3% of informative cases,respectively. 大肠癌MCC基因LOH率为34.;8%25; DCC基因为36
- Objective: To explore the role of the loss of heterozygosity (LOH) of DCC gene in the occurrence and development of primary hepatocellular cancer (HCC). 目的:了解结肠癌缺失基因(DCC基因)在原发肝癌发生发展中的作用。
- Objective: To investigate the relationship between the loss of heterozygosity(LOH) of MCC, DCC or YNZ22 loci and the development and progression of colorectal carcinoma. 目的:研究MCC、DCC基因和YNZ22位点杂合性丢失(LOH)与大肠癌发生发展的关系。
- METHODS: Twenty-three fresh resection samples of colorectal carcinomas were studied by the polymerase chain reaction (PCR) to detect the loss of heterozygosity of DCC. 方法:采用聚合酶链反应方法(polymerasechainreaction,PCR)对23例结直肠癌组织新鲜标本DCC基因杂合性缺失(lossofheterozygosity,LOH)进行研究。
- Objective To study the relationship between the loss of heterozygosity (LOH) at APC and MCC genetic loci and the incidence and development of esophageal carcinoma. 目的研究APC/MCC基因杂合性缺失(LOH)与食管癌发生发展的关系。
- Objective: To detect the status of loss of heterozygosity (LOH) on chromosome 8 in prostate carcinoma and high grade prostatic intraepithelial neoplasia (PIN). 目的:分析原发性前列腺癌及高级别前列腺上皮内肿瘤(PIN)8号染色体等位基因杂合性缺失(LOH)并探讨其意义。
- Microsatellite analysis showed that both loss of heterozygosity and microsatellite instability of FHIT gene existed in laryngeal carcinoma and the former was more common. 微卫星多态分析表明,FHIT基因在喉癌中既存在杂合性丢失,又存在微卫星不稳定现象,但以前者为主。
- Associations between compartment-specific TP53 status, loss of heterozygosity or allelic imbalance, and clinical and pathological characteristics were computed. 协会之间的隔间具体tp53地位,杂合性缺失或等位基因不平衡现象更加严重,临床及病理特征的计算机。
- Cong WM,Wu MC.Features of microsatellite instability and loss of heterozygosity of intrahepatic cholangiocarcinoma[J].Zhonghua Zhongliu Zazhi(Chin J Oncol),2002,24(2):141. [24]丛文铭;吴孟超.;肝内胆管癌的微卫星不稳定性和杂合性缺失特点[J]
- Method Polymerase chain reaction and restriction fragment length polymorphism were used to examine 40 oral malignant tumors for loss of heterozygosity at chromosome 3p. 方法应用聚合酶链反应限制性片段长度多态性分析方法对40例口腔鳞癌组织中3号染色体的等位基因杂合缺失进行测定。
- Ubiquitin associated protein 1(UBAP1) is a novel member of UBA domain protein family, located at human chromosome 9p21 22 where loss of heterozygosity frequently occurs in nasopharyngeal carcinoma. UBAP1(ubiquitinassociatedprotein 1)基因是最近克隆的一个定位于人类染色体 9p2 1 2 2鼻咽癌杂合性丢失高频区的泛肽相关蛋白家族新成员 .
- Relative survival(RS%),relative suspension growth(RSG%),mutation frequency at tk locus and percentages of slow growth mutant(SC%) were detected and loss of heterozygosity(LOH) of mutants were analyzed. 检测细胞相对存活率(RS%25)、相对悬浮增长率(RTG%25)、tk位点突变频率(M F)和缓慢生长集落的百分比(SC%25),同时对突变集落tk位点杂合性丢失(LOH)进行分析。