- The ovary index and the uterus index in leuprorelin group,high-dose and middle-dose of CHM groups had no differences from the normal group(P>0.05).
- Compare with the Leuprorelin group, Large dose CHM and middle dose CHM have the seem actions in the inhibitions of NMA induced rat model.
- They are normal control group (N), precocious puberty model group(P), Leuprorelin treatment group(L), large-dose CHM treatment group (C-L), middle-dose CHM treatment group (C-M) and low-dose CHM treatment group(C-low).
- The parameters of puberty and growth in high-dose and middle-dose of CHM groups were no differences from the normal group and the leuprorelin group, which were much lower than those in the model group.
- Keywords HPLC;Leuprorelin;Injection;Quantitative determi nation;Impurity limitation;
- Keywords solid-phase peptide synthesis;2-chlorotrityl chloride resin;C-terminal peptide N-alkylamides;Leuprorelin;