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- Knockout mice are used for general research and for the development of new treatments. 敲除小鼠通常被用于研究领域并且作为新治疗方法的试验对象。
- In contrast, knockout mice deficient in the endothelial form of NOS have larger infarcts than normal (62). 相反,NOS内皮组织不足的被击昏的老鼠比正常老鼠的梗塞要大(62)。
- We also detected BMD in APN gene knockout mice to evaluate the relationship between adiponectin and bone metabolism. 对骨代谢的初步研究采用检测小鼠骨密度(BMD)的方式。
- Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice. (有关普罗布考对载脂蛋白E基因敲除小鼠的动脉粥样硬化的位点专一作用)。
- Intercrossing of these black mice produces individuals homozygous for the disrupted allele, that is, knockout mice. 考试以前问过分子生物学的老师,但是她也觉得这段话很奇怪。
- The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice. 作者:佚名文章来源:本站原创点击数:更新时间:2007-9-18
- PLC and ERK1/2 activity in lungs from GIT1 knockout mice was reduced postnatally. GIT1基因敲除鼠肺内的PLC和ERK1/2活性在出生后降低了。
- Conclusion: The results shows that no significant alteration on glycometabolism or bone metabolism was found in APN gene knockout mice. 结论:脂联素基因剔除小鼠在基础状态下并无显著的糖代谢和骨代谢异常。
- Although they share two receptors,TACI and BCMA,transgenic and knockout mice in this system reveal that their functions are not redundant. 虽然它们共用2个受体BCMA和TACI,但转基因和基因敲除小鼠模型揭示它们各自功能并不冗余。
- Study mechanism of the stem cell therapy, stroke, acute renal failure, and spinal muscular atrophy by transgenic and knockout mice. 利用小鼠动物模式探讨干细胞治疗;中风;急性肾衰竭;人类脊髓肌肉萎缩症分子机制.
- They discovered how to inactivate, or knock out, single genes in laboratory animals.The result is known as "knockout mice. 他们发现了如何在实验动物上对单基因进行失活或敲除,得到所谓的“敲除小鼠”。
- Methods: We detected the weight and glucose level in APN gene knockout mice and evaluated the ability of glycometabolism by GTT and ITT. 方法:采用长期追踪野生型和该基因剔除纯合子小鼠的体重和空腹血糖水平,并进行葡萄糖耐量(GTT)和胰岛素耐量(ITT)试验以评价该小鼠的葡萄糖代谢能力。
- There were two kinds of mice in this study,which were vitamin D receptor knockout mice(VDR/-) and wild type mice(WT) in the same litter. 目的研究在四氧嘧啶诱导小鼠糖尿病发病过程中维生素D受体的作用。
- "The knockout mice are not exercising any more than the control mice used in the study.They're just burning more energy," Saltiel said. Saltiel说:“在这项研究中,基因敲除的小鼠并没有比对照组小鼠进行更多的运动。
- Knockout mice are used for general research and for the development of new treatments. International efforts aim to make them available in the near future for all genes. 敲除小鼠被用于普通研究和新疗法的开发。国际社会旨在通过努力使得在不远的将来能从它们身上获得所有的基因。
- In knockout mice, calcium transients showed a reduced rate of calcium uptake, and expression analysis showed reduced leels of calmodulin, phospholamban, and SERCA2. 在基因敲除小鼠,瞬时钙离子流摄取率减少;表达分析显示钙调蛋白、受磷蛋白和SERCA2水平降低。
- Cardiac-specific PINCH1 knockout or global PINCH2 knockout mice exhibit no basal cardiac phenotype, which may reflect a redundant role for these 2 PINCH proteins in myocardium. 心肌特异性的PINCH1蛋白或普遍表达的PINCH2蛋白被敲除后,老鼠没有表现出基本的心脏表型,这反映了这两种PINCH蛋白的作用具有重复性。
- Methods OPG knockout mouse model and control group were established. 方法建立OPG基因敲除小鼠模型,并设对照组;
- To seal the deal, the team created a knockout mouse that lacked the PYY gene. 研究小组构建了一种基因敲除小鼠,它缺乏PYY基因。
- Ultimately, knockout mice deeloped cardiac hypertrophy and heart failure, which inoles protein kinase C signal transduction but not the mitogen-actiated protein kinase pathway. 最终结果是基因敲除小鼠心脏发生肥厚和心衰,与蛋白激酶C信号转导有关而与丝裂原激活蛋白激酶途径无关。