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- As one of insulin sensitizing agents, rosiglitazone is mainly used to cure type 2 diabetes mellitus. 国外十余年的临床应用发现，罗格列酮可明显改善2型糖尿病病人的血脂紊乱，延缓动脉粥样硬化病变进展。
- Objective:To introduce the types and main roles of oral hypoglycemic drugs, emphasizing on the action mechanism and developmental trends of insulin sensitizing agent. 目的:介绍口服降糖药物的种类和主要作用,重点介绍胰岛素抵抗改善药物的作用机制和开发动态。
- Result &Conclusion: Insulin sensitizing agent with increasing insulin sensitivity and improving insulin resistance will be the hot point in the research of therapeutic drugs for type II diabetes. 结果与结论:具有提高胰岛素敏感性,改善胰岛素抵抗的胰岛素增敏剂将会成为II型糖尿病治疗药物的开发热点。
- Keywords 4-oxo-thiazolidine;insulin sensitizing agent;tert-butyl 4-iodobenzoate;synthesis; 羰基噻唑烷酮;胰岛素增敏剂;对碘苯甲酸叔丁酯;合成;
- insulin sensitizing agents 胰岛素增敏剂
- insulin sensitizing agent 胰岛素增敏剂
- Now the class of thiazolidinediones (TZDs) are the main agents for the treatment of type 2 diabetes in clinical by an insulin sensitizing mechanism. 噻唑烷二酮类药物(thiazolidinediones, TZDs)是近年来新研制开发得很有前途的胰岛素增敏剂，是目前临床上治疗2型糖尿病的主要药物。
- Hepatic insulin sensitizing substance(HISS),plays an important role in the pathogenesis of insulin resistance. 肝胰岛素敏感性物质(HISS)在胰岛素抵抗的发生机制中起重要作用。
- Body fat distribution is associated with insulin sensitivity. 身体的脂肪分布与胰岛素敏感性相关。
- The mixture radio of plastic and sensitizing agent also played an important role in the plastication. 塑料和敏化剂的配比也是影响塑化效果的一个重要作用。
- It showed that the variety of plastic and sensitizing agent and the vary of the weigh had a serious effect on the plastication in the rotational micro-wave heating molding. 实验证明，塑料的微波加热成型中，塑料和敏化剂的种类以及其加入量比的改变，都在极大程度上影响着塑料塑化效果。
- Exercise improves blood sugar control by increasing insulin sensitivity. 锻炼可以通过提高胰岛素感受性来改善血糖控制。
- Insulin sensitivity improved but high-density lipoprotein cholesterol (the "good" cholesterol) decreased. 虽然他们的胰岛素敏感性有所改善,但是其高密度脂蛋白胆固醇(即“好”胆固醇)则有所下降。
- Objective: To observe the influence of Huayu Sanqi Dan (HSD) on blood-lipid disorder and insulin sensitivity in type 2 diabetes mellitus (DM). 目的:观察化瘀三芪丹对2型糖尿病血脂异常及胰岛素敏感性的影响。
- It resulted in a decline in LH/FSH,LH,T levels,and improved insulin sensitivity. 结论:二甲双胍可改善临床症状,降低LH/FSH比值、LH、T水平,提高胰岛素的敏感性。
- When it is used as chemical sensitizing agent in the X-ray film,the sensitivity of the emulsion is increased and the stability of the film is improved. 在X射线胶片中它能提高乳剂的感光度,同时能提高胶片的稳定性;它是1种显影促进剂,缩短了显影时间;它还是1种表面活性剂,能减小卤化银的表面能量,有利于其它增感剂的作用。
- The results showed that 1.Obese rats were in hyperinsulinemia, low insulin sensitivity and insulin resistance. 得出以下结论:1.;高脂饲料诱发肥胖鼠存在高胰岛素血症，胰岛素敏感性下降，及胰岛素抵抗。
- Objective To investigate the effects of magnesium sulfate on insulin sensitivity of type 2 diabetes and IGT patients. 目的观察补镁(1周)前后,镁盐对2型糖尿病及IGT患者胰岛素敏感性及糖代谢的影响。
- Additional experiments suggested that osteocalcin regulates insulin sensitivity through adiponectin. 骨钙素通过脂联素调节胰岛素敏感性。
- So insulin sensitizer is not only for the short term but also can benefit the lipid disorders. 胰岛素增敏剂使患者不仅在短期内受益，还有助于调整血脂紊乱。
