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- High sense mutation of HVR 1 gene was found. （4）HVR1基因有义突变率相当高。
- Mutations in the ABCA 1 gene cause Tangier disease. ABCA 1基因的突变引起Tangier病 (TD)。
- Over expression of PAI 1 gene leads to mesangial ECM accumulation. 首次建立了系膜细胞PAI 1的过度表达体系 ,证实细胞过度表达PAI 1可以直接导致ECM的积聚。
- The carnosinase 1 gene produces an enzyme called carnosinase. 肌肽酶1基因翻译表达肌肽酶。
- GCH 1 gene mutation is only one of reasons to the DRD patients onset. GCH-1基因突变只是部分DRD患者的发病原因。
- Study on expression of IRF?1 gene in human leukemia with RT?PCR and the silver sequence techniques. 逆转录-聚合酶链反应银染分析IRF-1基因在白血病中的表达
- Results 1. The emm 1 gene and emm 3 gene were amplified and identified by blast to CDC data bank. 结果从40381137(T1)和31281187(T3)A组链球菌株的基因组成功克隆emm基因,经测序及blast后分别确认为emm1型和emm3型;
- Objectives To construct a recombinant vector containing fragments of emm 1 genes and emm 3 gene that are the type specific epitopes of streptococcus pyogenes. 目的构建含A组链球菌M蛋白基因(emm基因)1型和3型特异性抗原决定簇基因的重组质粒。
- Genetic heterogeneity existed among clinical isolates,and the major class of the flp 1 gene was class 2. Aa临床分离菌株flp 1基因具有遗传多样性 ,基因型主要为 2型
- Type III collagen is one main type of IMC, which is encoded by Col3a1(collagen type III alpha 1 gene). III型胶原是IMC的主要类型之一,其编码基因为Col3a1(Collagen type III alpha 1 gene)。
- Objective To investigate in Chinese population the relationship between GTP cyclohydrolase 1 gene mutation and phenotypes of dopa-responsive dystonia(DRD). 目的 分析国人多巴敏感性肌张力障碍（DRD）患者三磷酸鸟苷环羟化酶1（GCH-1）基因突变与表现型的关系。
- The organization of the Ers-MIH 1 gene is iden t ical to that of the molt-inhibiting hormone gene of Charybdis feriatus and Cancer pagurus. 中华绒螯蟹MIH 1基因的组织方式与斑纹?和食用黄道蟹的MIH基因相同。
- Compared with Gambia isolate, the FEN 1 gene of FCC1/HN isolate has 6 base pairs deletion at 1 581- 1 586 bp and other 5 bp mutations. 测序表明,恶性疟原虫FCC1/HN株与国外Gambia株和3D7株的FEN 1基因序列有较高的同源性。
- The expression of IL 1 gene was low in HCE16/3 cells normally. When HCE16/3 cells were co cultured with fibroblasts, however, the expression of IL 1 gene was significantly up? 在正常情况下 ,HCE16 /3细胞IL 1基因表达水平很低 ,但在与纤维母细胞作共同培养时 ,IL 1基因的表达水平明显上调。
- The successful cloning and expressing of vp 1 gene become thebasis for the immunological studies of VP1 protein and themanufacture of genetic engineering vaccine of CAV. vp1基因的成功克隆与表达，为VP1蛋白的免疫学研究和CAV基因工程疫苗的研制奠定了基础。
- The frequency of Gly972Arg mutation of IRS 1 gene was 2% in type 2 diabetic patients and control subjects in Chinese, lower than in Caucasian population. IRS- 1基因 Gly972 Arg突变频率在病例组和对照组均为 2%25 ,明显低于白人。
- AML 1 gene abnormalities, including both chromosome translocation and mutation (point mutation, insertion, deletion mutation, et al), which lead to the lost of transcript activation, are general in acute leukemia. 在急性白血病中常见AML1基因结构异常，包括平衡易位及突变(如点突变、插入或缺失突变等)，导致AML1的转录活性丧失，提示此基因功能缺失在急性白血病的发生及发展中起着重要作用。
- This city has a population of more than 1,000,000. 这个城市人口超过一百万。
- METHODS: Eukaryotic expression vectors pTL 8/apical membrane antigen 1 (AMA 1) (tTA) and pTL 8/AMA 1(rtTA)gene which express trans activator (tTA) or reverse trans activator(rtTA), respectively, and AMA 1 gene of Plasmodium falciparum were constructed. 方法 :首先构建恶性疟原虫顶端膜抗原 1(AMA 1)基因和转录激活因子 (tTA或rtTA)基因的真核表达质粒pTL 8/AMA 1和pTL 8/AMA 1(rtTA) ,并大量制备这两种质粒及表达转录抑制子 (tTS)的质粒pUHS6 1。
- Methods Four members of a DRD family were performed phenylalanine(Phe) and BH 4 loading test as well as urinary pterin analysis. Mutation analysis of GTP cyclohydrolase 1 gene(GCH1) was done in all family members. 方法 对DRD的一家系 4人进行苯丙氨酸 (Phe)和BH4负荷试验、尿蝶呤谱分析 ,对所有成员进行三磷酸鸟苷环化水解酶 1基因 (GCH1)检测。
