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- The histone deacetylases inhibitors (HDACIs) are potent inducers of growth arrest, differentiation and apoptosis of tumor cells, and have entered clinical trials for both solid and liquid tumors. HDAC抑制剂能够引起肿瘤细胞生长停滞、诱导肿瘤细胞分化和凋亡。
- Objective To explore the blockade effect of phenylbutyrate (PB),a histone deacetylase inhibitor, on the in vitro biological function of AML1/ETO to reverse its transcription repression and induce Kasumi-1 cells to differentiate and apoptosis. 目的 探讨组蛋白脱乙酰化酶抑制剂苯丁酸钠 (PB)体外阻断AML1 ETO的生物学功能 ,消除AML1 ETO的转录抑制 ,诱导Kasumi 1细胞生长抑制、分化和凋亡作用。
- Histone deacetylase inhibitors had been used to treat cancer and leukemia. 组蛋白去乙酰化酶抑制剂已经越来越多的被用于治疗肿瘤和白血病。
- histone deacetylases inhibitor 组蛋白脱乙酰化酶抑制剂
- The pharmacological actions of histone deacetylase inhibitors and their potential clinical uses were reviewed. 综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。
- With intensive study, the mechanism of histone deacetylase inhibitors in leukemia has been paid more and more attention. 随着对组蛋白乙酰化的深入研究,组蛋白去乙酰化酶抑制剂在白血病中的作用机制越来越受到人们的关注。
- Objective: To observe the synergistic cytotoxicity of histone deacetylase inhibitors TSA or DP with paclitaxel on the NSCLC cell lines, and to elucidate the possible mechanism. 目的:探讨组蛋白去乙酰化酶抑制剂与紫杉醇联合应用,协同抑制NSCLC细胞系的作用和机制。
- Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins , and specifically modulate some gene expression. 组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平,并对一些非组蛋白成分产生影响,从而调节某些特定基因的表达。
- Cyclic tetrapeptide histone deacetylases inhibitors containing L-methylphenylalanine:cyclo(-Ab7-Aib-Phe(X-Me)-D-Pro-); 含甲基苯丙氨酸坏四肽结构cyclo(-Ab7-Aib-Phe(X-Me)-D-Pro-)
- Cyclic tetrapeptide histone deacetylases inhibitors containing L-phenylalanine: cyclo(-Ab7-Aib-Phe-D-Pro-); 含有苯丙氨酸的环四肽结构cyclo(-Ab7-Aib-Phe-D-Pro-)
- Keywords NF-kappa B;tumor necrosis factor;inflammation;histone deacetylase inhibitor;FK228; 肿瘤坏死因子;炎症;组蛋白去乙酰化酶抑制剂;FK228;
- Keywords Acetylation,Drosophila,hsp gene,polytene chromosome, histone deacetylase inhibitor; 乙酰化;果蝇;热休克基因;多线染色体;去乙酰化酶抑制剂;
- Keywords malignant tumors of head and neck;histone acetylation;histone deacetylation;histone deacetylase inhibitor; 头颈部恶性肿瘤;组蛋白乙酰化;组蛋白去乙酰化;组蛋白去乙酰化酶抑制剂;
- histone deacetylases inhibitors 组蛋白脱乙酰基酶抑制剂
- Advances in pharmacological study of histone deacetylase inhibitors 组蛋白去乙酰酶抑制剂的药理学研究进展
- Histone deacetylase inhibitor 组蛋白去乙酰化酶抑制剂
- Munster PN,Troso-Sandoval T,Rosen N,Rifkind R,Marks PA,Richon VM.The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells.Cancer Res 2001; 李丰;吴一迪;王芸庆;宋今丹.;丁酸钠诱导的人大肠癌细胞成熟分化中的表型变化
- Sensitive assay system for inhibitor screening and kinetic assays of HDAC1 (histone deacetylase 1). 一种用于抑制剂筛选和HDAC1动力学检测的敏感检测系统。
- Histone acetyltransferases(HAT) and histone deacetylases(HDACs) as the corresponding enzymes regulate the change of histones in two antagonist forms,acetylated or deacetylated. 组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)调节组蛋白乙酰化程度,HDAC在基因表达和染色体形成等方面起着重要的调节作用。
- Mechanism of histone deacetylase inhibitors for treatment of hematological cancer and their clinical research 组蛋白去乙酰化酶抑制剂治疗血液系统肿瘤的作用机制及临床应用
