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- In rats dependence to flurazepam, hippocampal nNOS increased but without statistical significance. 而对氟西泮抗痫依赖组则与对照组差别无统计学意义。
- Conclusion NO may play a role in rats tolerance and dependence to the anticonvulsant action of flurazepam. 结论NO可能是介导氟西泮抗痫耐受性和依赖性的因素之一。
- Method Animal models of tolerance and dependence to flurazepam were established. 方法建立大鼠对氟西泮抗痫耐受性和依赖性的模型。
- Total NOS activity increased dramatically both in flurazepam tolerane and dependene rats. 两组NOS活性均显著高于各自的对照组。
- Aim To study the role of nitric oxide by measuring the expression and activity of nitric oxide synthase in hippocampus of rats tolerance and dependence to the anticonvulsant action of flurazepam. 目的通过测定大鼠对氟西泮抗痫耐受性和依赖性时海马中一氧化氮合酶(NOS)蛋白表达及活性的变化,探讨一氧化氮(NO)在此过程中可能的作用。方法建立大鼠对氟西泮抗痫耐受性和依赖性的模型。
- Keywords FLZ;Ginkgo biloba extract;oxidized low density lipoprotein;macrophage;endothelial cell;apoptosis; 银杏叶提取物;氧化低密度脂蛋白;巨噬细胞;内皮细胞;凋亡;
- Keywords flurazepam;tolerance;dependence;nitric oxide(NO);nitric oxide synthase(NOS); 氟西泮;耐受性;依赖性;一氧化氮(NO);一氧化氮合酶(NOS);
- 5. Conclusion NO may play a role in rats tolerance and dependence to the anticonvulsant action of flurazepam. 结论NO可能是介导氟西泮抗痫耐受性和依赖性的因素之一。
- Molecular mechanism of the tolerance to flurazepam and reversal of tolerance with flumazenil in genetically epilepsy-prone rats 氟马西尼逆转惊厥易感大鼠氟西泮耐受性的分子机制
- Changes of nitric oxide synthase in hippocampus of rats tolerant to and dependent on the anticonvulsant action of flurazepam 大鼠对氟西泮抗痫耐受和依赖时海马中一氧化氮合酶的变化
- Modification of GABAA receptor subunit mRNA content in audiogenic seizure rat cortex and hippocampus following tolerance to flurazepam 氟西泮耐受听源性惊厥大鼠脑皮质运动区和海马区GABAA受体亚单位mRNA含量的变化
- FLZ (=flurazepam) 氟胺安定
- Poisoning by flurazepam 氟胺安定中毒
- Flurazepam Dihydrochloride 盐酸氟胺安定
- flurazepam hydrochloride 盐酸氟西泮, 盐酸氟安定, 盐酸氟胺安定
- Flurazepam measurement 氟胺安定测量
- Flurazepam Monohydrochloride 盐酸氟胺安定
- flurazepamn. [药]氟胺安定;氟二乙氨乙基安定(安眠药)