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- Hence, we investigated whether RNA-dependent DNA methylation might operate in human cancers to mediate epigenetic silencing using the endogenous gene CDH1 as a potential target. 因此,我们用内源的CDH1基因作为可能的靶基因研究RNA依赖的DNA甲基化是否也在人类的癌症中参与了对基因的转录沉默。
- epigenetic silencing 外遗传沉默
- It's no use silencing opposition. 压制反对意见是无济於事的。
- Abstract: BACKGROUND: Gene promoter methylation is an epigenetic eent leading to gene silencing. 摘要:背景:基因启动子甲基化是一种可引起基因沉默的表观遗传事件。
- Gene silencing is a kind of epigenetic phenomenon discovered in transgenic plants in recent years. 摘要基因沉默是近几年来在转基因植物中发现的一种后生遗传现象。
- But how did epigenetic regulation arise? 但如何做后生调控出现的吗?
- The church was wrong in silencing Galileo. 教会压制伽俐略是错误的。
- It is no use silencing opposition. 压制反对意见是无济于事的。
- "I wasn't worried about silencing people. “我不会为那些对我保持沉默的球迷犯愁。
- It includes epigenetic uranium impregnations in sandstone. 它意味着外生的铀进入到沙岩中。
- There are four known mechanisms for epigenetic inheritance. 现有四种已知的机理可以说明表观遗传。
- Epigenetics in human disease and prospects for epigenetic therapy. 表遗传改变与人类疾病,包括肿瘤。
- DNA methyltransferase inhibitor 5-Aza-CdR can induce demethylation in the promoter region of RASSF1A. It can also reverse epigenetic transcriptional silencing caused by methylation and induce the re-expression of RASSF1A in QBC-939. DNA甲基转移酶抑制剂5-Aza-CdR能够诱导RASSF1A基因启动子区域去甲基化,并通过该机制诱导RASSF1A基因在人胆管癌细胞系QBC-939中的表达。
- "Silencing Shot" now does only 50% of weapon damage instead of 75%. “沉默射击”现在造成50%25武器伤害而不是之前的75%25。
- DNA methylation plays a key role in transgene silencing. DNA甲基化是引起外源基因沉默的主要原因。
- Man goes into the noisy crowed to drown his own clamour of silenc. 人走进喧哗的群众里去,为的是要淹没他自己的沉默的呼号。
- Histone lysine methylation plays a key role in epigenetic regulation. 摘要组蛋白赖氨酸的甲基化在表观遗传调控中起着关键作用。
- The low-frequency silencing effects of the box were confirmed by using actu... 通过实际应用证实了消声箱的低频消声效果。
- The Mississippi Valley-type (MVT) lead -zinc deposits are the classic epigenetic hydrothermal ores. 密西西比河谷型矿床为后生热液矿床。
- Geneticists have yet to decipher the complex code by which epigenetic marks interact with the other components of the genome. 目前,遗传学家还未破解外遗传标签与基因组其他组成之间,产生互动的复杂编码。