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- Objective To study drug resistant mechanism and reversal of glioma we established C 6 MDR drug resistant cell line(C 6/adr). 目的 为研究脑胶质瘤的耐药、机理及逆转 ,建立了C6耐阿霉素细胞株 (C6/adr)MDR细胞系。
- Objective:The study was designed to examine the expressions of vascular endothelial growth factor C(VEGF C) mRNA and protein in human breast cancer cell line MCF 7 and drug resistant cell line MCF 7/Adr. 目的 :检测血管内皮生长因子C(vascularendothelialgrowthfactorC ,VEGF C)mRNA和蛋白在人乳腺癌细胞株MCF 7及其耐药株MCF 7/Adr中的定位、定性表达。
- Reversion of drug resistance in intrinsic drug resistant cell line GRC 1 逆转肾癌细胞系GRC-1耐药的实验与机理研究
- drug resistance cell line 耐药细胞株
- CEP reverses drug resistance of K562/ADR cell line partly and decreases the expression of bcl-2 in K562/ADR cell line. CEP可部分逆转K5 62 /ADR细胞的耐药性,其机制可能与降低bcl 2的表达有关。
- THE CHARACTERIZATION IN MULTIDRUG RESISTANT MECHANISMS OF A HUMAN OVARIAN CARCINOMA DRUG RESISTANT CELL LINE COC_1/DDP 人卵巢癌多药耐药细胞系COC_1/DDP的耐药机制探讨
- The deficiency of CD95(APO-1/Fas)in expression and function on drug resistant cell line MCF-7/Adr 乳腺癌MCF-7/Adr耐药细胞CD95分子的多态性表达和功能缺陷
- Establishment of a Human Nasopharyngeal Carcinoma Drug Resistant Cell Line CNE2/DDP and Screening of Drug Resistant Genes 人鼻咽癌顺铂耐药细胞系(CNE2/DDP)的建立及耐药相关基因的筛选
- Objective To investigate the effect of drug resistance by arsenic trioxide (As 2O 3) and its possible mechanism in human breast cancer cell line MCF 7/ADM. 目的 探讨三氧化二砷 (As2 O3 )对人乳腺癌MCF 7/ADM细胞耐药性的逆转作用及其相关机制。
- Salvicine (SAL) was used to reverse the drug resistance in a gemcitabine-resistant pancreatic cancer cell line (SW1990-GEM). RT-PCR, flow cytometry and MTT assay were employed to evaluate the effect of reversing drug resistance by salvicine. 选用沙尔威辛(SAL)进行逆转耐药实验,采用了RT-PCR法、流式细胞仪和MTT法,评估SAL逆转耐药的效果。
- This study was done to establish a human lung adenocarcinoma cell line SPC-A1 with the characterization of docetaxel resistance, to investigate its biological mechanism of drug resistance and how to reverse the resistance. 本研究拟通过体外诱导耐药建立肺癌SPC-A1的多西他赛耐药细胞系,以便于进一步研究其耐药机制及耐药逆转。
- Conclusion A multidrug resistance cell line (SPC-A-1/CDDP) from human lung adenocarcinoma is established.It can be used to downstream experiment. 结论本研究建立了稳定的人肺腺癌多药耐药细胞系（SPC-A-1/CDDP），可应用于下游实验。
- Drug resistant cell line 耐药细胞系
- AIM and METHODS: Matrine (50mg/L) potentiated the cytotoxicity of daunorubicin (DNR) in human leukemia multidrug resistance cell line K562/A02 by MTT assay. 方法和结果：经MTT法发现苦参碱50mg/L能增加K562/A02对柔红霉素的敏感性，使柔红霉素半数抑制浓度（IC50）由14?92mg/L降至8?29mg/L，部分逆转了K562/A02对柔红霉素耐药性，逆转倍数为1?80倍。
- AIM To study drug resistance mechanism of gastrointestinal tumor, we developed MKN28/VCR, MKN45/VCR which were vincristine-resistant cell lines of human gastric cancer. 目的为研究消化道肿瘤的耐药机制,建立了2株体外人胃腺癌长春新碱耐药细胞系MKN28/VCR和MKN45/VCR。
- The SPC-A1/Docetaxel cell line showed high resistance to docetaxel, and had the characteristic of multidrug resistance. The cell line could be useful for the study of drug resistant mechanism and its reversal of docetaxel. 经体外诱导耐药建立的SPC-A1/Docetaxel表现出对多西他赛较高的耐药性,并呈多药耐药特性,耐药细胞系SPC-A1/Docetaxel与亲本细胞SPC-A1的生物学特性有明显差异,可用于对多西他赛的耐药机制和逆转耐药研究。
- Objective：To study the effects of oridonin on inducing the multi-drug resistant cell line K562/A02 to apoptosis and reversing their multi-drug resistance. 目的：探讨冬凌草甲素诱导多药耐药细胞系K562/A02凋亡、逆转耐药性的作用。
- Drug resistant cell lines 耐药细胞系
- Objective To investigate the restoration of the subcellular distribution of daunorubicin in the P glycoprotein mediated multidrug resistant cell line K562/ADR by quercetin. 目的研究槲皮素处理前后柔红霉素(DNR)在耐药细胞株K562/ADR亚细胞结构的不同分布。
- Objective: To investigate the inhibitory effect of ampelopsin (AMP) combined with adriamycin (ADR) on growth of human leukemia multidrug resistant cell line K562/ADR. 目的：研究蛇葡萄素与阿霉素合用对人白血病多药耐药细胞株K562/ADR增殖的抑制作用及其机制。
