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- Objective To prepare the cucurbitacin B loaded poly(lactic-co-glycollic acid) nanospheres(CuB-PLGA-NS). 目的制备葫芦素B聚乳酸羟基乙酸纳米球。
- With the cucurbitacin, cucumber, such as acid can help the lung, stomach, liver detoxification. 含有的葫芦素、黄瓜酸等还能帮助肺、胃、肝排毒。
- Objective To study the distribution of cucurbitacin B loaded PLGA nanospheres in mice. 目的 研究葫芦素B聚乳酸-羟基乙酸毫微球小鼠体内分布。
- Conclusion The results provide an important base to further study treatment of oral carcinoma using Cucurbitacin BE. 结论实验结果为葫芦素BE治疗口腔癌的进一步研究提供了重要的依据。
- Cucurbitacin B sc 0.1mg/kg or 0.2mg/kg obviously inhibited the expression of Fas and FasL, and number of apoptotic cells in dose-dependent manner. sc葫芦素B 0 .;1mg/kg和 0 2mg/kg可使Fas和FasL的表达明显降低并呈剂量依赖性。
- Results Two kinds of cancer cell lines had higher sensitivity to Cucurbitacin BE,Relative anti-tumor activitics(RAA) were 345 and 148,respectively. 结果葫芦素BE对两种癌细胞系均有较高的相对抗肿瘤活性（RAA值分别为345、148）。
- Objective To observe the effects that Cucurbitacin BE with kindsof biological activities kill oral squamous cell carcinoma. 目的观察具有多种生物活性的葫芦素BE对口腔鳞癌细胞的杀伤作用。
- Jinxiu-such as padding, color and whistling kite (plate described in chicken), woodblock printing technique, cucurbitacin, etc. 诸如扎染、彩锦绣、哨口风筝（板鹞）、木版印画、工艺葫芦等。
- Abstract: Aulacophora femoralis chinensis Weise are inclined to select the Cucurbitacin -containing plants as their primary host plants. 黄足黄守瓜（Aulacophra femoralis chinensis Weise）选择葫芦科植物作为其主要的寄主植物。
- Methods After admistration to mice by iv, HPLC was used to determine the concentration of cucurbitacin B of plasma, heart, liver, spleen, lung, kidney and brain respectively. 方法 小鼠尾静脉给药， HPLC法测定葫芦素B在小鼠血浆、心、肝、脾、肺、肾、脑中的浓度。
- Conclusion Cucurbitacin B loaded PLGA nanospheres show passive targeting to liver.The established HPLC method can be used for cucurbitacin B biodistribution study. 结论 葫芦素B聚乳酸-羟基乙酸毫微球可实现肝脏被动靶向，所建立的HPLC法用于葫芦素B的体内分布研究，结果良好。
- cucurbitacin E-2-O-β-D-glucopyranoside 药西瓜苦苷
- Keywords capillary zone electrophoresis;Pedicellus Melo;cucurbitacin B; 毛细管区带电泳;甜瓜蒂;葫芦素B;
- Keywords Cucurbitacin B;alcohol;jaundice;liver injury;lipid peroxidation; 葫芦素B;酒精;黄疸;脂质过氧化;
- Keywords Cucurbitacin;Anti-tumor;Drug combination;G_2/M arrest;Toxicity test; 葫芦素;抗肿瘤;联合用药;G_2/M期阻滞;毒性实验;
- Keywords cucurbitacin B;human serum albumin nanoparticle;HPLC;assay; 葫芦素B;人血清白蛋白纳米粒;高效液相色谱法;含量测定;
- Keywords cucurbitacin B;poly（lactic-co-glycollic acid）;nanospheres;solvent-evaporation method; 葫芦素B;聚乳酸-羟基乙酸;纳米球;溶剂挥发法;
- Keywords Cucurbitacin;Solid lipid nanoparticles;Preparation;Quality evaluation;Phannacokinetics;Tissue distribution; 葫芦素;固体脂质纳米粒;制备;制剂学评价;药动学;组织分布;
- Keywords cucurbitacin B;self-microemulsifying drug delivery system（SMEDDS）;formulation optimization;pseudo-ternary phase diagram; 葫芦素B;自微乳化药物传递系统;处方优化;假三元相图;
- Keywords HIV;Anti-HIV-1 drug;Natural compounds;Schisandra rebriflora;Hemsleya jinfushanensis;Lignan;Tripenoid;Cucurbitacin; 抗HIV-1化合物;天然化合物;红花五味子;金佛山雪胆;木脂素;三萜;葫芦素;
