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- And chromosome aberration of bone marrow cells of mice was observed. 观察小鼠骨髓细胞染色体畸变。
- The chromosome aberration rates were 15.3% for children with mental retardation and 3.7% for control group. 智力低下儿童染色体畸变率为15·3%25,对照组为3·7%25;
- The results of Ames and micronucleus tests were negative, but the result of chromosome aberration test was positive. 风湿平Ames试验、小鼠骨髓细胞微核试验结果均为阴性; CHL细胞染色体畸变试验结果为阳性,经过S9代谢活化后致突变作用降低。
- The mental retardation is correlative with the chromosome aberration and the fragile site expression rate. 提示精神发育迟滞与染色体的畸变率和脆性部位的表达率有一定的相关性。
- Objective:To study the relationship between the chromosome aberration and the male infertility. 目的研究男性染色体异常与男性不育之间的关系。
- Conclusion: The mental retardation is correlative with the chromosome aberration and the fragile site expression rate. 结论：提示精神发育迟滞与染色体的畸变率和脆性部位的表达率有一定的相关性。
- Conclusions Rises of chromosome aberration and micronuclei frequency are caused by lowdose and long... 结论长期小剂量外照射可引起染色体畸变和微核检出率升高。
- CONCLUSION: Sodium pentachlorophenol could induce DNA damage and chromosome aberration of CHO cells. 结论： 五氯酚钠能诱发CHO细胞DNA损伤和染色体畸变。
- Forcron could decrease the mitotic index and lead to various types of chromosome aberration. 异丙莠能降低蚕豆根尖细胞有丝分裂指数并诱导染色体产生多种类型的畸变。
- The result howed that amobam has obvious effect on inducing chromosome aberration and micronuclei,and inducing some binuclei cells. 以小鼠为材料，检测了农药代森铵水剂的毒理遗传效应。
- Water organic pollutants induced gene mutation and chromosome aberration in abundant season were tested by Ames test and micronucleus test (MNT). 用Ames实验、微核实验检测了丰水期水样中有机污染物引起的基因突变与染色体畸变；
- After irradiation the counts of leukocyte and lymphocyte, and the rates of micronuclear and chromosome aberration of lymphocyte were ob. 观察白细胞及淋巴细胞计数,淋巴细胞微核及淋巴细胞染色体畸变。
- Mothods: Genotoxicity and teratogenicity of DSL were examined by micronucleus of PCE,chromosome aberration of CHL and teralogenic test. 方法:采用小鼠骨髓嗜多染红细胞(PCE)微核试验、中国仓鼠肺细胞(CHL)染色体畸变试验及致畸试验,对受试物DSL进行了遗传毒性及致畸性检测。
- ZResults There was positive correlation between micronuclei frequency and cumulative dose,as well as between chromosome aberration and cumulative dose. 结果染色体畸变率和淋巴细胞微核检出率与接触射线累积剂量呈正相关。
- Objective To study effect of low dose Mitomycin C(MMC) on chromosome aberration of bone marrow cells of mice treated by 2.0Gy X ray. 目的观察丝裂霉素C(MMC)对辐射损伤小鼠染色体畸变的影响。
- Objective: Traditional Ames test, in vitro mammalian chromosome aberration test, single cell gel electrophoresis assay have been used widely in monitoring chemical toxicity. 目的:传统的Ames实验、体外哺乳动物细胞染色体畸变实验、单细胞凝胶电泳实验已广泛用于化学品毒性的监测,但用于综合评价化学品的遗传学毒性还不够完善。
- The results show that EtO can pass placental barrier easily and transfer into the pre- natal mice and indbce the chromosome aberration in hemapoietic stem cell of fetal liver. 实验结果表明：EtO这个小分子的水溶性化台物能容易地通过胎盘屏障转移到胎鼠，造成胎肝造血干细胞染色体损伤的效应，我们必须对EtO潜在性遗传危害给予足够的重视。 同时胎肝微核试验又是一种快速、简易的检测方法。
- MATERIAL AND METHODS: Chromosome aberration test,micronucleus test of bone marrow cell and sperm shape abnormality test in mice were used in this study. 材料与方法:采用小鼠睾丸染色体畸变试验,小鼠骨髓微核实验以及小鼠精子畸形实验方法。
- Methods Sperm abnormality test, Chromosome aberration of spermatogonia and unscheduled DNA synthesis (UDS) test in male mouse reproductive cells were used in the study. 方法采用小鼠精子畸形试验、精原细胞染色体畸变试验和小鼠精子非程序DNA合成(UDS)试验。
- So sodium benzoate is chromosome clastogen. And the mutagenesis to male is greater than that to female. Isochromatid break is the main type of chromosome aberration. 结果显示:小鼠骨髓细胞微核试验及小鼠骨髓细胞染色体畸变试验均呈阳性(P<0.;01);证明苯甲酸钠是染色体断裂剂;而且对雄性动物的致突变作用更大;所引起的染色体结构畸变以染色体断裂为主要类型。
