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- Aim To design a new synthetic route of cefoperazone sodium. 目的设计新的头孢哌酮钠的合成路线。
- Objective To evaluate the quality of cefoperazone sodium and sulbactam sodium for injections at present. 目的对国产注射用头孢哌酮钠舒巴坦钠的质量现状进行评价。
- The stability of cefoperazone sodium and sulbactam sodium for injection was relatively good. 考察了注射用头孢哌酮钠舒巴坦钠的稳定性。
- To study the stability of cefoperazone sodium and sulbactam sodium for injection. 考察注射用头孢哌酮钠舒巴坦钠的稳定性。
- Conclusion Cefoperazone sodium and tazobactam sodiun for injection are promising anti-infection drugs. 结论注射用头孢噻肟钠他唑巴坦钠是一种很有发展前途的抗感染的药物。
- Results The all-ergic reaction was most common in the case reports on ADR of cefoperazone sodium and sulbactam sodium for injection. 结果注射用头孢哌酮钠/舒巴坦钠导致变态反应的案例比较常见。
- Objective To summarize Adverse Drug Reaction(ADR)of cefoperazone sodium and sulba-ctam sodium for injection,prove information for rational usage of it in the clinical. 目的分析注射用头孢哌酮钠/舒巴坦钠不良反应发生情况,为临床合理用药提供参考。
- The HPLC method for the determination of cefoperazone and sulbactam and related substances in cefoperazone sodium and sulbactam sodium for injection was established. 用HPLC法测定注射用头孢哌酮钠舒巴坦钠中头孢哌酮和舒巴坦的含量及其有关物质。
- Objective:To simultaneous determination of two main components in the compound Cefoperazone Sodium and Sulbactam Sodium injection without the separation of the compound. 目的:采用褶合曲线分析法不经分离同时测定头孢哌酮钠舒巴坦钠注射剂中哌酮钠和舒巴坦钠二组分的含量。
- Objective:To establish the HPLC method for the determination of cefoperazone and tazobactam and its related substances in cefoperazone sodium and tazobactam sodium for injection. 目的:用HPLC法测定注射用头孢哌酮钠他唑巴坦钠中头孢哌酮和他唑巴坦的含量及其有关物质。
- However, the detection rate of fibrinogen increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. 随着氯霉素、硫酸庆大霉素、乳酸环丙沙星浓度降低，血浆中纤维蛋白检出率升高；随着头孢哌酮钠浓度降低，血浆中纤维蛋白原检出率亦降低。
- Results The coagulation time of fibrinogen in plasma increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. 结果随着氯霉素、硫酸庆大霉素和乳酸环丙沙星浓度的降低，血浆中纤维蛋白原的凝固时间延长；而随着头孢哌酮钠浓度的降低，凝固时间反而缩短。
- Conclusion The concentrations of cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate showed significant influence on the coagulation time and detection rate of fibrinogen in plasma. 结论头孢哌酮钠、氯霉素、乳酸环丙沙星、硫酸庆大霉素等抗菌素及其浓度变化对血浆中纤维蛋白原的凝固时间和检出率有显著影响。
- The coagulation time of fibrinogen in plasma increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. 随着氯霉素、硫酸庆大霉素和乳酸环丙沙星浓度的降低，血浆中纤维蛋白原的凝固时间延长；而随着头孢哌酮钠浓度的降低，凝固时间反而缩短。
- The concentrations of cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate showed significant influence on the coagulation time and detection rate of fibrinogen in plasma. 头孢哌酮钠、氯霉素、乳酸环丙沙星、硫酸庆大霉素等抗菌素及其浓度变化对血浆中纤维蛋白原的凝固时间和检出率有显著影响。
- The power X-ray experimental results of cefoperazone sodium crystal showed that the product in this paper was in triclinic crystal system while that from the previous process was in monoclinic system. 新工艺收率高,产品经粉末X-射线衍射证明为三斜晶,热稳定性和引湿性实验证明与原工艺产品(单斜晶)比较,稳定性好。
- Methods Add the cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate at different concentrations into plasma and determine the coagulation time and content of fibrinogen. 方法采用凝固法，以加入抗菌素后血浆中纤维蛋白原的凝固时间为指标，观察不同浓度的头孢哌酮钠、氯霉素、乳酸环丙沙星和硫酸庆大霉素对血浆纤维蛋白原的影响。
- Methods The inpatients treated with cefoperazone sodium and tazobactam sodium were divided into control group and test group.The latter received the guide for drug use and the former did not. 方法将临床上使用头孢哌酮钠/他唑巴坦钠的患者,分为对照组和试验组,对照组未对患者作药物指导,试验组对医护人员及患者进行药物指导。
- Research of Cefoperazone Sodium impurity 头孢哌酮钠杂质研究
- Keywords cefoperazone sodium;sulbactam sodium;HPLC; 头孢哌酮钠;舒巴坦钠;高效液相色谱;
