c) converting AVNA into 7-[2-(aminothiazol-4-yl)-2- (tert- butoxycarboxy methoxyimino)- acetamido]-3- vinyl-3-cephem-4- carboxylic acid (TBO) using acylation reaction;

• 采用头孢克肟侧链酯(简称MBT)与AVNA进行酰化反应,得到头孢克肟特丁基酯(简称TBO)