but if somebody has lamivudine resistance and was switched to entecavir they need to have a very profound early suppression or I am going to add on adefovir or tenofovir in that setting.

• 但是如果患者拉米夫定耐药后换用恩替卡韦，那就需要早期加用阿德福韦酯或替诺福韦了。