The traditional empiric method has being used until now in the design to determine this parameter. 設計中迄今一直沿用經驗法確定這一重要參數。
Nietzsche's Enlightenment predecessors had already established the adequacy of empirical methods to explain what goes on in the nonhuman world. 尼採的啟蒙運動前輩們已經建立了足夠的經驗方法去解釋在非人的世界上在發生什麼事情。
Their results, however, can be very wrong if the molecule being computed is not similar enough to the molecules in the database used to parametrize the method. 但是如果計算的分子與參數化該方法時使用的分子結構不相近時，半經驗方法可能給出完全錯誤的結果。
