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- Aim To design a new synthetic route of cefoperazone sodium. 目的設計新的頭孢哌酮鈉的合成路線。
- Objective To evaluate the quality of cefoperazone sodium and sulbactam sodium for injections at present. 目的對國產注射用頭孢哌酮鈉舒巴坦鈉的質量現狀進行評價。
- The stability of cefoperazone sodium and sulbactam sodium for injection was relatively good. 考察了注射用頭孢哌酮鈉舒巴坦鈉的穩定性。
- To study the stability of cefoperazone sodium and sulbactam sodium for injection. 考察注射用頭孢哌酮鈉舒巴坦鈉的穩定性。
- Conclusion Cefoperazone sodium and tazobactam sodiun for injection are promising anti-infection drugs. 結論注射用頭孢噻肟鈉他唑巴坦鈉是一種很有發展前途的抗感染的藥物。
- Results The all-ergic reaction was most common in the case reports on ADR of cefoperazone sodium and sulbactam sodium for injection. 結果注射用頭孢哌酮鈉/舒巴坦鈉導致變態反應的案例比較常見。
- Objective To summarize Adverse Drug Reaction(ADR)of cefoperazone sodium and sulba-ctam sodium for injection,prove information for rational usage of it in the clinical. 目的分析注射用頭孢哌酮鈉/舒巴坦鈉不良反應發生情況,為臨床合理用藥提供參考。
- The HPLC method for the determination of cefoperazone and sulbactam and related substances in cefoperazone sodium and sulbactam sodium for injection was established. 用HPLC法測定注射用頭孢哌酮鈉舒巴坦鈉中頭孢哌酮和舒巴坦的含量及其有關物質。
- Objective:To simultaneous determination of two main components in the compound Cefoperazone Sodium and Sulbactam Sodium injection without the separation of the compound. 目的:採用褶合曲線分析法不經分離同時測定頭孢哌酮鈉舒巴坦鈉注射劑中哌酮鈉和舒巴坦鈉二組分的含量。
- Objective:To establish the HPLC method for the determination of cefoperazone and tazobactam and its related substances in cefoperazone sodium and tazobactam sodium for injection. 目的:用HPLC法測定注射用頭孢哌酮鈉他唑巴坦鈉中頭孢哌酮和他唑巴坦的含量及其有關物質。
- However, the detection rate of fibrinogen increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. 隨著氯黴素、硫酸慶大黴素、乳酸環丙沙星濃度降低,血漿中纖維蛋白檢出率升高;隨著頭孢哌酮鈉濃度降低,血漿中纖維蛋白原檢出率亦降低。
- Results The coagulation time of fibrinogen in plasma increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. 結果隨著氯黴素、硫酸慶大黴素和乳酸環丙沙星濃度的降低,血漿中纖維蛋白原的凝固時間延長;而隨著頭孢哌酮鈉濃度的降低,凝固時間反而縮短。
- Conclusion The concentrations of cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate showed significant influence on the coagulation time and detection rate of fibrinogen in plasma. 結論頭孢哌酮鈉、氯黴素、乳酸環丙沙星、硫酸慶大黴素等抗菌素及其濃度變化對血漿中纖維蛋白原的凝固時間和檢出率有顯著影響。
- The coagulation time of fibrinogen in plasma increased with the decreasing concentrations of chloromycetin, gentamycin sulfate and ciprofloxacin lactate, but decreased with the decreasing concentration of cefoperazone sodium. 隨著氯黴素、硫酸慶大黴素和乳酸環丙沙星濃度的降低,血漿中纖維蛋白原的凝固時間延長;而隨著頭孢哌酮鈉濃度的降低,凝固時間反而縮短。
- The concentrations of cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate showed significant influence on the coagulation time and detection rate of fibrinogen in plasma. 頭孢哌酮鈉、氯黴素、乳酸環丙沙星、硫酸慶大黴素等抗菌素及其濃度變化對血漿中纖維蛋白原的凝固時間和檢出率有顯著影響。
- The power X-ray experimental results of cefoperazone sodium crystal showed that the product in this paper was in triclinic crystal system while that from the previous process was in monoclinic system. 新工藝收率高,產品經粉末X-射線衍射證明為三斜晶,熱穩定性和引濕性實驗證明與原工藝產品(單斜晶)比較,穩定性好。
- Methods Add the cefoperazone sodium, chloromycetin, ciprofloxacin lactate and gentamycin sulfate at different concentrations into plasma and determine the coagulation time and content of fibrinogen. 方法採用凝固法,以加入抗菌素后血漿中纖維蛋白原的凝固時間為指標,觀察不同濃度的頭孢哌酮鈉、氯黴素、乳酸環丙沙星和硫酸慶大黴素對血漿纖維蛋白原的影響。
- Methods The inpatients treated with cefoperazone sodium and tazobactam sodium were divided into control group and test group.The latter received the guide for drug use and the former did not. 方法將臨床上使用頭孢哌酮鈉/他唑巴坦鈉的患者,分為對照組和試驗組,對照組未對患者作藥物指導,試驗組對醫護人員及患者進行藥物指導。
- Research of Cefoperazone Sodium impurity 頭孢哌酮鈉雜質研究
- Keywords cefoperazone sodium;sulbactam sodium;HPLC; 頭孢哌酮鈉;舒巴坦鈉;高效液相色譜;